INT134045

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0.47

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cytoplasm (Jak2, Stat3) nucleus (Jak2, Stat3) cell differentiation (Jak2)
histone binding (Jak2) DNA binding (Stat3) signal transducer activity (Stat3)
Jak2 (Rattus norvegicus)
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 84.00 Quite High
Opioid 4 75.00 Quite High
ischemia 3 74.08 Quite High
MU agonist 1 50.08 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 3 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that OIC occurs via the JAK2 regulation of PI3K pathway-dependent STAT3, Akt, and GSK-3 beta, with GSK-3 beta contributing a central role in acute OIC.
JAK2 Regulation (regulation) of STAT3
1) Confidence 0.26 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.13 Pain Relevance 0.47

General Comments

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