INT134049

Context Info Confidence 0.37 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.22 Pain Relevance 0.77

cytoplasm (Jak2, Gsk3b) cytosol (Jak2, Gsk3b) nucleus (Jak2, Gsk3b) cell differentiation (Jak2) histone binding (Jak2) carbohydrate metabolic process (Gsk3b)

Jak2 (Rattus norvegicus) Gsk3b (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 4 99.46 ischemia 3 90.04 Morphine 4 83.04 MU agonist 1 81.60

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 3 90.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.

JAK2 Positive_regulation (mediator) of GSK-3 beta associated with opioid

1) Confidence 0.37 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16517948 Disease Relevance 0.22 Pain Relevance 0.77

General Comments

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