INT134061

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.46
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Anatomy Link Frequency
muscle tissues 1
nucleus 1
fibroblasts 1
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 9 99.20 Very High Very High Very High
Kinase C 5 87.16 High High
opiate 1 74.36 Quite High
Opioid 1 70.68 Quite High
tolerance 7 68.24 Quite High
cytokine 18 62.76 Quite High
Inflammation 29 62.36 Quite High
Spinal cord 3 60.96 Quite High
Glutamate 7 16.44 Low Low
Deafferentation 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 143 100.00 Very High Very High Very High
Targeted Disruption 138 98.24 Very High Very High Very High
Hypersensitivity 2 88.32 High High
Brain Injury 5 87.36 High High
Stress 228 86.44 High High
Aging 80 86.16 High High
Drug Induced Neurotoxicity 5 82.16 Quite High
Death 78 77.76 Quite High
Lifespan 44 66.32 Quite High
INFLAMMATION 42 62.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To ensure that the enhanced sensitivity was caused by the knockdown of SOD2 expression, we transduced the fibroblasts with a recombinant adenovirus that expressed a Sod2 gene whose mRNA was resistant to the siRNA expressed by the transgene.
Transcription (expressed) of Sod2 in fibroblasts
1) Confidence 0.68 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.73 Pain Relevance 0
SOD2 mRNA levels were increased in muscle tissues of Klotho transgenic mice as were SOD2 protein levels (234%) relative to normal mice.
Transcription (levels) of SOD2 in muscle tissues associated with targeted disruption
2) Confidence 0.64 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 1.04 Pain Relevance 0.03
Regarding gene expression, Al-Regaiey and colleagues (2005) reported an increase of nearly 50% in hepatic mRNA expression of SOD2 in GHR-KO mice presumably mediated via increased FOXO protein and decreased Akt expression.
Transcription (expression) of SOD2
3) Confidence 0.64 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.35 Pain Relevance 0
The relative mRNA levels for the antioxidant enzymes CuZnSOD, MnSOD, CAT and Gpx-1 were determined by reverse transcriptase polymerase chain reaction (RT-PCR) in groups where differences in activities between control and treated samples were observed.
Spec (determined) Transcription (levels) of MnSOD
4) Confidence 0.58 Published 2006 Journal Biogerontology Section Abstract Doc Link 16518720 Disease Relevance 0 Pain Relevance 0.90
Phosphorylation and degradation of IkB, the inhibitory subunit that sequesters the NF-kB complex in the cytoplasm, releases NF-kB which can traslocate to the nucleus and activate the transcription of genes that promote resistance to apoptosis, such as MnSOD, Bcl-2 and members of the Inhibitor of Apoptosis Proteins (IAPs) family.
Transcription (transcription) of MnSOD in nucleus associated with apoptosis
5) Confidence 0.10 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.91 Pain Relevance 0.08
Little is known, however, on the molecular mechanisms that govern transcription of the MnSOD gene.
Transcription (transcription) of MnSOD
6) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.42 Pain Relevance 0.17

General Comments

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