INT134070

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC2) aging (ERCC2) chromosome segregation (ERCC2)
helicase activity (ERCC2) extracellular matrix organization (ERCC2) DNA binding (ERCC2)
Anatomy Link Frequency
EM-2 1
ERCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 1 99.68 Very High Very High Very High
Analgesic 3 98.00 Very High Very High Very High
Pain 1 96.48 Very High Very High Very High
peripheral neuropathy 2 93.24 High High
Endogenous opioid 2 75.00 Quite High
Neuropathic pain 2 75.00 Quite High
Root ganglion neuron 1 43.36 Quite Low
dorsal root ganglion 1 36.40 Quite Low
neuralgia 2 25.00 Low Low
Spinal nerve ligature 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 2 96.48 Very High Very High Very High
Peripheral Neuropathy 2 93.24 High High
Neuropathic Pain 6 75.00 Quite High
Neutropenia 3 66.16 Quite High
Neurodegenerative Disease 3 66.08 Quite High
Herpes Simplex Virus 1 61.52 Quite High
Cold Sores 2 59.76 Quite High
Stomach Cancer 24 58.12 Quite High
Stress 1 58.08 Quite High
Ganglion Cysts 2 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, TS and XPD polymorphisms were found to be associated with RR, and these polymorphisms could be used as predictive markers.
XPD Binding (associated) of
1) Confidence 0.27 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0.29 Pain Relevance 0.05
Endomorphin-2 (EM-2) is a carboxy-amidated tetrapeptide that binds the mu-opioid receptor with high affinity and is analgesic in several animal models of pain.
EM-2 Binding (binds) of in EM-2 associated with pain, analgesic and opioid receptor
2) Confidence 0.13 Published 2007 Journal Pain Section Abstract Doc Link 17395375 Disease Relevance 0.29 Pain Relevance 0.32
In all assay systems, EM1 was more potent than EM2 and l-glutathione, a major intracellular water-soluble antioxidant.
EM1 Binding (potent) of
3) Confidence 0.07 Published 2006 Journal FEBS J. Section Abstract Doc Link 16519691 Disease Relevance 0.18 Pain Relevance 0.15

General Comments

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