INT134077

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 28
Disease Relevance 8.38
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vasp) cytoplasm (Vasp)
Anatomy Link Frequency
platelet 6
hearts 2
blood 1
Vasp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 104 99.24 Very High Very High Very High
adenocard 46 98.88 Very High Very High Very High
tolerance 22 97.64 Very High Very High Very High
long-term potentiation 39 97.40 Very High Very High Very High
antagonist 37 94.56 High High
amygdala 441 91.28 High High
Glutamate 9 84.68 Quite High
Angina 37 82.88 Quite High
ischemia 8 58.40 Quite High
Hippocampus 9 41.08 Quite Low
Disease Link Frequency Relevance Heat
Thrombosis 290 96.20 Very High Very High Very High
Hemorrhage 50 92.64 High High
Coronary Artery Disease 38 91.28 High High
Anxiety Disorder 228 90.48 High High
Emergencies 57 88.92 High High
Hypertension 19 87.52 High High
Cv General 4 Under Development 19 87.08 High High
Diabetes Mellitus 19 86.96 High High
Stroke 27 85.92 High High
Myocardial Infarction 173 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NTG markedly reduced the vasodilator-stimulated phosphoprotein (VASP) serine 239 phosphorylation (specific substrate of cGMP-activated protein kinase I; cGK-I) in tolerant hearts.
Phosphorylation (phosphorylation) of VASP in hearts
1) Confidence 0.80 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.21 Pain Relevance 0.30
NTG markedly reduced the vasodilator-stimulated phosphoprotein (VASP) serine 239 phosphorylation (specific substrate of cGMP-activated protein kinase I; cGK-I) in tolerant hearts.
Phosphorylation (phosphorylation) of vasodilator-stimulated phosphoprotein in hearts
2) Confidence 0.80 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.21 Pain Relevance 0.33
For example, studies employing hippocampal cultures found that LTP-induced alterations in pre- (synapsin and synaptophysin) and postsynaptic (GluR1) proteins were associated with increases in the phosphorylation of the actin cytoskeleton regulators VASP and RhoA [26], and impaired following application of an actin polymerization inhibitor [24].
Phosphorylation (phosphorylation) of VASP associated with long-term potentiation
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.20 Pain Relevance 0.23
Of particular interest to the present study, VASP was found to have increased levels of phosphorylation at Ser-239 [26], a site that is preferentially phosphorylated by PKG [50], suggesting that VASP phosphorylation may be PKG-dependent.
Phosphorylation (phosphorylation) of VASP
4) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.29 Pain Relevance 0.16
In vitro studies in hippocampal area CA1 have shown that LTP-induced alterations in pre- and postsynaptic proteins are blocked by inhibitors of actin polymerization [24] and associated with increases in the phosphorylation of the actin cytoskeleton regulators VASP and RhoA [26].
Phosphorylation (phosphorylation) of VASP associated with long-term potentiation
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.21 Pain Relevance 0.31
The effect of thienopyridines can be demonstrated by the persistence of VASP phosphorylation induced by prostaglandin E1, even with the simultaneous addition of ADP [12,13].
Phosphorylation (phosphorylation) of VASP
6) Confidence 0.67 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.44 Pain Relevance 0.08
Analysis of VASP phosphorylation by flow cytometry.
Phosphorylation (phosphorylation) of VASP
7) Confidence 0.67 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.41 Pain Relevance 0.08
The phosphorylation of VASP is regulated by the cyclic adenosine monophosphate cascade.
Phosphorylation (phosphorylation) of VASP associated with adenocard
8) Confidence 0.67 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.59 Pain Relevance 0.09
Levels of VASP phosphorylation/dephosphorylation reflect P2Y12 inhibition/activation [11].
Phosphorylation (dephosphorylation) of VASP
9) Confidence 0.67 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.48 Pain Relevance 0.09
Levels of VASP phosphorylation/dephosphorylation reflect P2Y12 inhibition/activation [11].
Phosphorylation (phosphorylation) of VASP
10) Confidence 0.67 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.48 Pain Relevance 0.09
After signing of informed consent, she was randomized into group B of this study, and also participated in the vasodilator stimulated phosphoprotein (VASP) phosphorylation state and genetic laboratory substudies.
Phosphorylation (phosphorylation) of VASP
11) Confidence 0.58 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.62 Pain Relevance 0.05
After signing of informed consent, she was randomized into group B of this study, and also participated in the vasodilator stimulated phosphoprotein (VASP) phosphorylation state and genetic laboratory substudies.
Phosphorylation (phosphorylation) of vasodilator stimulated phosphoprotein
12) Confidence 0.58 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.68 Pain Relevance 0.05
The phosphorylation status of VASP correlates with P2Y12 receptor inhibition, whereas its non-phosphorylation state correlates with the active form of the P2Y12 receptor.
Phosphorylation (phosphorylation) of VASP
13) Confidence 0.58 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.53 Pain Relevance 0.10
Examiners analyzing the VASP phosphorylation state were blinded to the patient-related data.
Spec (analyzing) Phosphorylation (phosphorylation) of VASP
14) Confidence 0.58 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.27 Pain Relevance 0.07
What did the VASP phosphorylation study show?
Phosphorylation (phosphorylation) of VASP
15) Confidence 0.58 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.51 Pain Relevance 0.08
If inhibition of the platelet P2Y12 receptor by clopidogrel occurs, ADP fails to cause a decrease in VASP phosphorylation and the PRI converges to 0.
Phosphorylation (phosphorylation) of VASP in platelet
16) Confidence 0.51 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.06 Pain Relevance 0.04
Flow cytometric determination of VASP phosphorylation state strongly correlated with the inhibition of ADP-induced platelet aggregation resulting from specific P2Y12 blockade by a specific antagonist of the P2Y12 receptor (AR-C69931MX) [6].
Phosphorylation (phosphorylation) of VASP in platelet associated with antagonist
17) Confidence 0.51 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.31 Pain Relevance 0.09
A flow cytometric analysis of VASP phosphorylation can be recommended as an index (the gold standard) of the efficacy of P2Y12 inhibitors [21].


Phosphorylation (phosphorylation) of VASP
18) Confidence 0.51 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.32 Pain Relevance 0.09
Aspirin and abciximab did not interfere with VASP phosphorylation [9,19].
Phosphorylation (phosphorylation) of VASP associated with aspirin
19) Confidence 0.51 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.32 Pain Relevance 0.10
Dual-color flow cytometric analysis was performed on a Becton Dickinson FACS Calibur cytometer to compare the two tested conditions, and to evaluate the capacity of ADP to inhibit VASP phosphorylation for each sample.
Phosphorylation (phosphorylation) of VASP
20) Confidence 0.51 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox