INT134086

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 2.11
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc32a1)
Anatomy Link Frequency
synaptic vesicles 2
developmental stages 1
forebrains 1
GABAergic neurons 1
Slc32a1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 206 100.00 Very High Very High Very High
Glutamate 40 100.00 Very High Very High Very High
Morphine 6 99.46 Very High Very High Very High
Neurotransmitter 41 98.52 Very High Very High Very High
GABAergic 115 97.80 Very High Very High Very High
monoamine 20 97.60 Very High Very High Very High
antinociception 2 97.04 Very High Very High Very High
tolerance 1 95.60 Very High Very High Very High
Spinal cord 82 91.04 High High
Action potential 11 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 184 98.52 Very High Very High Very High
Umbilical Hernia 120 76.24 Quite High
Cleft Palate 80 75.64 Quite High
Congenital Anomalies 20 5.00 Very Low Very Low Very Low
Respiratory Failure 15 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 15 5.00 Very Low Very Low Very Low
Body Weight 15 5.00 Very Low Very Low Very Low
Anxiety Disorder 15 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we found that mice tolerant to morphine exhibited the significant increase in the protein levels of the vesicular glutamate transporter 1 and the synaptic vesicle-specific small G protein Rab3A, but not vesicular glutamate transporter 2 and vesicular gamma-aminobutyric acid transporter.
Positive_regulation (increase) of vesicular gamma-aminobutyric acid transporter in synaptic vesicle associated with glutamate and morphine
1) Confidence 0.65 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16522322 Disease Relevance 0 Pain Relevance 1.00
We showed that both GABA and glycine contents were increased in the VGAT-/- forebrain, but not an excitatory neurotransmitter glutamate, which is transported into synaptic vesicles by vesicular glutamate transporters.
Positive_regulation (increased) of VGAT in synaptic vesicles associated with glutamate, neurotransmitter and gaba
2) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.45 Pain Relevance 0.43
Increase of overall GABA and glycine contents in VGAT-/- forebrains
Positive_regulation (Increase) of VGAT in forebrains associated with gaba
3) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.50 Pain Relevance 0.39
In C. elegans, the mutational inactivation of VGAT also leads to an increase in GABA immunoreactivity in GABAergic neurons [24].
Positive_regulation (inactivation) of VGAT in GABAergic neurons associated with gaba and gabaergic
4) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.29 Pain Relevance 0.51
Therefore, the VGAT-floxneo allele allowed for Cre-mediated conditional inactivation of the VGAT gene, and mice carrying these alleles will be useful in examining VGAT function at different developmental stages and in distinct cell types.


Positive_regulation (inactivation) of VGAT gene in developmental stages
5) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.56 Pain Relevance 0.28
Our results, summarized in Table 1, demonstrate that a relatively high level of VGAT transcripts was detected in the absence of a VGLUT1 signal in GFPpos samples, and conversely, a similarly high level of expression of VGLUT1 was determined for GFPneg cells in which VGAT RNA was undetectable.
Positive_regulation (level) of VGAT
6) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0.08 Pain Relevance 0.12
To address functional importance of VGAT during embryonic development, we generated global VGAT knockout mice and analyzed them.


Positive_regulation (importance) of VGAT associated with targeted disruption
7) Confidence 0.41 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3023674 Disease Relevance 0.23 Pain Relevance 0.29

General Comments

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