INT13409

Context Info Confidence 0.75 First Reported 1987 Last Reported 2008 Negated 1 Speculated 0 Reported most in Abstract Documents 52 Total Number 53 Disease Relevance 14.17 Pain Relevance 12.23

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1) cytoplasm (NEUROD1)

Anatomy Link Frequency CHO 4 monocytes 2 neutrophils 2 neurons 2 macrophages 1 NEUROD1 (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 19 100.00 Kinase C 15 100.00 Kappa opioid receptor 1 100.00 tetrodotoxin 9 99.96 cINOD 2 99.76 gABA 26 99.72 agonist 40 99.64 Neuropeptide 11 99.50 neuralgia 2 99.50 Action potential 2 99.40

Disease Link Frequency Relevance Heat Amyloidosis 6 99.96 Multiple Myeloma 7 99.88 Dementia 11 99.18 Hypothermia 1 99.16 Cancer 14 99.04 Chronic Renal Failure 2 98.92 Fatigue 4 98.36 Respiratory Failure 1 97.88 Pancreatitis 4 97.80 Alzheimer's Dementia 10 97.36

Sentences Mentioned In

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this cell line, endogenous beta2-adrenergic receptors (beta2-ARs) are coexpressed with the exogenous delta-ORs.

Gene_expression (coexpressed) of beta2

1) Confidence 0.75 Published 1999 Journal Cell Prolif. Section Abstract Doc Link 10614711 Disease Relevance 0.07 Pain Relevance 0.49

Decreased expression of beta 2-adrenergic receptors may limit the expected functional improvement.

Gene_expression (expression) of beta 2

2) Confidence 0.75 Published 1999 Journal Nervenarzt Section Abstract Doc Link 10637819 Disease Relevance 0.74 Pain Relevance 0.14

Coexpression of beta3 subunits had small but significant effects on the kinetic and voltage-dependent properties of Nav1.3 currents in HEK 293 cells, but coexpression of beta1 and beta2 subunits had little or no effect on Nav1.3 properties.

Gene_expression (coexpression) of beta2 in HEK associated with nav1.3

3) Confidence 0.75 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487618 Disease Relevance 0.24 Pain Relevance 1.10

However, cotransfection with either TR beta 1 or TR beta 2 expression plasmids produced no effect on the ER alpha or ER beta mediated induction of PPE.

Gene_expression (expression) of beta 2

4) Confidence 0.75 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578528 Disease Relevance 0.08 Pain Relevance 0

NSAIDs upregulate beta 2-integrin expression on human neutrophils through a calcium-dependent pathway.

Gene_expression (expression) of beta 2 in neutrophils associated with cinod

5) Confidence 0.75 Published 1997 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 9218092 Disease Relevance 0 Pain Relevance 0.19

The former mechanism seems to be a selective increase in the expression of the beta 2-adrenoceptors.

Gene_expression (expression) of beta 2

6) Confidence 0.75 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989252 Disease Relevance 0.51 Pain Relevance 0.24

These data indicate that GABA and GABAA receptor subunits alpha 1 and beta 2/3 are expressed by separate populations of neurons in macaque LGN that are differentially regulated by visual activity.

Gene_expression (expressed) of beta 2 in LGN associated with gaba

7) Confidence 0.75 Published 1996 Journal Vis. Neurosci. Section Abstract Doc Link 8737273 Disease Relevance 0 Pain Relevance 0.23

In this study, we stably coexpressed the human neuronal alpha 4 and beta 2 nAChR subunits in human embryonic kidney (HEK) 293 cells and studied its pharmacological and regulatory properties. [3H]Cytisine bound to stably transfected cells with high affinity (KD value, 0.2 +/- 0.04 nM) and with a Bmax value of 1359 +/- 91 fmol/mg protein.

Gene_expression (coexpressed) of beta 2 in neuronal

8) Confidence 0.75 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558445 Disease Relevance 0.18 Pain Relevance 0.29

An increased expression of PLC-beta3 and PKC-alpha and -beta2 was also evidentiated at the longer time points explored, when the effects of ATRA in preservation of the differentiated morphology were maximal.

Gene_expression (expression) of beta2

9) Confidence 0.75 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12866655 Disease Relevance 0.08 Pain Relevance 0.09

On histology, there was increased vasodilatation, marked infiltration with neutrophils and monocytes/macrophages, and increased expression of beta 2 integrins in lesional vs. normal skin.

Gene_expression (expression) of beta 2 in macrophages

10) Confidence 0.75 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15270877 Disease Relevance 0 Pain Relevance 0

The model comprised CHObeta2 SPAP cells; Chinese hamster ovary cells expressing human beta2 adrenoceptors and a secreted placental alkaline phosphatase (SPAP) reporter gene with multiple cAMP response elements (CREs) in its promoter region.

Gene_expression (expressing) of beta2 in ovary

11) Confidence 0.75 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16036225 Disease Relevance 0 Pain Relevance 0.20

Odontoblasts express neuronal isoforms of alpha2 and beta2 subunits of sodium channels.

Gene_expression (express) of beta2 in Odontoblasts associated with sodium channel

12) Confidence 0.75 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16831873 Disease Relevance 0.16 Pain Relevance 0.53

The effects of the antidepressant drugs clomipramine (CLOM), desipramine (DMI), tianeptine (TIAN) and of norfluoxetine (NORF, the active metabolite of fluoxetine), were investigated in CHO cells expressing human beta2 adrenoceptors and a secreted placental alkaline phosphatase (SPAP) reporter gene to determine their actions on cyclic AMP-driven gene transcription.

Gene_expression (expressing) of beta2 associated with desipramine, antidepressant and fluoxetine

13) Confidence 0.75 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.36

In the melanocyte this signalling is redundant due to the high expression of alpha1 and beta2-adrenoceptors.

Gene_expression (expression) of beta2 in melanocyte

14) Confidence 0.75 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.09

Using specific antibodies for immunohistochemistry, we have now detected sodium channel beta1 and beta2 subunits in sensory cell bodies within control human postmortem sensory ganglia (78% of small/medium (< or = 50 microm) and 68% of large (> or = 50 microm) cells); their changes in cervical sensory ganglia after avulsion injury paralleled those described for SNS/PN3 alpha-subunits.

Gene_expression (detected) of beta2 in ganglia associated with injury and sodium channel

15) Confidence 0.65 Published 2001 Journal Neuroreport Section Abstract Doc Link 11234750 Disease Relevance 0.28 Pain Relevance 0.34

Sodium channel beta1 and beta2 subunits parallel SNS/PN3 alpha-subunit changes in injured human sensory neurons.

Gene_expression (parallel) of beta2 in sensory neurons associated with sodium channel

16) Confidence 0.65 Published 2001 Journal Neuroreport Section Title Doc Link 11234750 Disease Relevance 0.24 Pain Relevance 0.58

It also inhibited the function of human nicotinic acetylcholine receptors composed of the alpha4 and beta2 subunits, but this effect was only partial and apparent at high concentrations.

Gene_expression (composed) of beta2

17) Confidence 0.65 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17234181 Disease Relevance 0.06 Pain Relevance 0.48

Respiratory depression involves beta3 containing GABA(A) receptors whereas hypothermia is largely mediated by GABA(A) receptors containing beta2 subunits.

Gene_expression (containing) of beta2 in Respiratory associated with hypothermia, gaba, depression and respiratory failure

18) Confidence 0.65 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17073666 Disease Relevance 0.39 Pain Relevance 0.64

However, cotransfection with either TR beta 1 or TR beta 2 expression plasmids produced no effect on the ER alpha or ER beta mediated induction of PPE.

Gene_expression (cotransfection) of beta 2

19) Confidence 0.65 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578528 Disease Relevance 0.08 Pain Relevance 0

Furthermore, we show that Neurod1/2/6 and Lhx1/5, which act downstream of Ptf1a, control distinct aspects of peptidergic differentiation.

Gene_expression (/) of Neurod1

20) Confidence 0.65 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18721803 Disease Relevance 0.07 Pain Relevance 0.65

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