INT13413

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Context Info
Confidence 0.07
First Reported 1991
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 87.32 High High
Clonidine 2 85.60 High High
noradrenaline 5 85.08 High High
Potency 1 83.40 Quite High
antagonist 5 82.04 Quite High
cerebral cortex 2 76.60 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all three tissue preparations, large responses to both alpha 1-receptor activation (increases in inositol phosphate accumulation) and alpha 2-receptor activation (decreases in forskolin-stimulated cyclic AMP accumulation) were observed.
Negative_regulation (decreases) of Gene_expression (activation) of alpha 2
1) Confidence 0.07 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1671087 Disease Relevance 0 Pain Relevance 0.36
Therefore, it can be surmised that the activation of angiotensin II AT1 receptors may reduce the transduction of the alpha 2-adrenoceptors and thus the alpha 2-mediated vasodepressor responses.
Negative_regulation (reduce) of Gene_expression (transduction) of alpha 2-mediated
2) Confidence 0.02 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7813592 Disease Relevance 0 Pain Relevance 0.31

General Comments

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