INT134130

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.38
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP17A1) small molecule metabolic process (CYP17A1) endoplasmic reticulum (CYP17A1)
CYP17A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 2 99.52 Very High Very High Very High
endometriosis 2 98.88 Very High Very High Very High
dexamethasone 10 5.00 Very Low Very Low Very Low
iatrogenic 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 2 99.52 Very High Very High Very High
Adrenal Cancer 274 99.12 Very High Very High Very High
Endometriosis (extended) 4 98.88 Very High Very High Very High
Obesity 14 84.64 Quite High
Osteoporosis 6 78.08 Quite High
Hepatotoxicity 1 66.44 Quite High
Insulin Resistance 6 60.24 Quite High
Congenital Anomalies 3 58.64 Quite High
Polycystic Ovary Syndrome 28 56.96 Quite High
Testosterone Deficiency 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: The aim of the study was to test whether the COMT, CYP1A1 and CYP17 genes influence the risk of developing adenomyosis and endometriosis.
Spec (whether) Gene_expression (influence) of CYP17 associated with endometriosis and dismenorea
1) Confidence 0.65 Published 2006 Journal Hum. Reprod. Section Abstract Doc Link 16527884 Disease Relevance 0.35 Pain Relevance 0.26
Finally, while the 17,20-lyase activity of P450c17 towards ?
Gene_expression (activity) of P450c17
2) Confidence 0.38 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.80 Pain Relevance 0
Finally, while the 17,20-lyase activity of P450c17 towards ?
Gene_expression (activity) of 17,20-lyase
3) Confidence 0.33 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.80 Pain Relevance 0
PGZ but not RGZ inhibited the expression of the CYP17 and HSD3B2 genes.
Gene_expression (expression) of CYP17
4) Confidence 0.31 Published 2008 Journal Cardiovasc Diabetol Section Body Doc Link PMC2576082 Disease Relevance 0.43 Pain Relevance 0

General Comments

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