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Context Info
Confidence 0.16
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.71
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
spinal cord 2
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 4 100.00 Very High Very High Very High
Opioid 3 99.14 Very High Very High Very High
Spinal cord 30 98.22 Very High Very High Very High
cocaine 7 97.80 Very High Very High Very High
Morphine 8 96.60 Very High Very High Very High
antagonist 8 95.72 Very High Very High Very High
narcan 3 94.00 High High
Enkephalin 3 90.36 High High
Multiple sclerosis 26 79.68 Quite High
Inflammation 37 79.04 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 132 98.62 Very High Very High Very High
Stress 116 89.36 High High
Endometriosis (extended) 11 89.12 High High
INFLAMMATION 40 79.04 Quite High
Recurrence 5 76.32 Quite High
Disease 23 62.72 Quite High
Apoptosis 2 49.72 Quite Low
Depression 1 38.64 Quite Low
Cushing's Syndrome /


2 36.92 Quite Low
Sprains And Strains 2 20.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest the opioid peptides and their receptors play a major role in the regulation of HPA function.
Regulation (role) of Regulation (regulation) of HPA associated with opioid
1) Confidence 0.16 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6328347 Disease Relevance 0.12 Pain Relevance 1.29
The present results suggest an important stimulatory role for DA in regulation of HPA activity, and a role for both DA and 5-HT in the adrenocortical stimulation by cocaine.
Regulation (role) of Regulation (regulation) of HPA associated with dopamine and cocaine
2) Confidence 0.14 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1671094 Disease Relevance 0 Pain Relevance 1.00
The studies reviewed in this bioessay indicate that the ovarian cycle and, in particular, the female's estradiol background modulates the response of the HPA and HPG axes to acute stressors.
Regulation (modulates) of Regulation (response) of HPA
3) Confidence 0.07 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.29 Pain Relevance 0
Moreover, glucocorticoid receptor expression in spinal cord is lower in the EAE+S group at 12 days than in the control group, indicating a possible dysregulation of HPA feedback regulation (high levels of corticosterone not correlated with increased expression of GR) which indicates that hypofunction of the axis increases vulnerability and severity of EAE.
Spec (possible) Regulation (dysregulation) of Spec (possible) Regulation (regulation) of HPA in spinal cord associated with multiple sclerosis and spinal cord
4) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.30 Pain Relevance 0.26

General Comments

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