INT134145

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 5.32
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
cartilage 6
PGE2 4
monocytes 2
colon 2
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 102 100.00 Very High Very High Very High
COX2 16 100.00 Very High Very High Very High
rheumatoid arthritis 4 100.00 Very High Very High Very High
cINOD 16 99.84 Very High Very High Very High
Inflammation 53 98.40 Very High Very High Very High
aspirin 16 91.32 High High
COX-2 inhibitor 8 87.16 High High
IPN 2 83.00 Quite High
Arthritis 4 82.32 Quite High
Pain 4 81.32 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 101 100.00 Very High Very High Very High
Cancer 13 100.00 Very High Very High Very High
Rheumatoid Arthritis 4 100.00 Very High Very High Very High
INFLAMMATION 67 99.64 Very High Very High Very High
Colon Cancer 6 88.20 High High
Inflammatory Pain 2 83.00 Quite High
Apoptosis 3 82.56 Quite High
Arthritis 4 82.32 Quite High
Pressure And Volume Under Development 2 82.12 Quite High
Fever 2 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that mPGES-1 expression is upregulated in animal models of rheumatoid arthritis and in patients suffering from OA [4,5] and is downregulated by anti-inflammatory drugs [6,7]. mPGES-1 expression is regulated by several transcription factors, such as early growth response-1 (Egr-1) and NF-?
Negative_regulation (downregulated) of Gene_expression (expression) of mPGES-1 associated with inflammation, cinod, rheumatoid arthritis and osteoarthritis
1) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.19 Pain Relevance 0.68
The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase (mPGES-1).
Negative_regulation (inhibition) of Gene_expression (expression) of mPGES-1 in PGE2
2) Confidence 0.46 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529823 Disease Relevance 0.28 Pain Relevance 0.20
Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
Negative_regulation (inhibition) of Gene_expression (Distinction) of mPGES-1 associated with cox2
3) Confidence 0.42 Published 2010 Journal Biochem. Pharmacol. Section Title Doc Link 20067770 Disease Relevance 0.58 Pain Relevance 0.53
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Negative_regulation (suppressed) of Gene_expression (expression) of microsomal PGE synthase-1
4) Confidence 0.42 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.59 Pain Relevance 0.21
We conclude that the inhibitory effect of ellagic acid on PGE2 release from monocytes is due to a suppressed expression of COX-2, mPGEs-1 and cPLA2alpha, rather than a direct effect on the activities of these enzymes.
Negative_regulation (suppressed) of Gene_expression (expression) of mPGEs-1 in monocytes
5) Confidence 0.41 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.45 Pain Relevance 0.17
However, repeated treatments with HNE prevented the decline of COX-2 and mPGES-1 expression that occurred with a single aldehyde addition.
Negative_regulation (decline) of Gene_expression (expression) of mPGES-1
6) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875653 Disease Relevance 0.13 Pain Relevance 0.03
Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
Negative_regulation (inhibition) of Gene_expression (Distinction) of microsomal prostaglandin E synthase-1 associated with cox2
7) Confidence 0.36 Published 2010 Journal Biochem. Pharmacol. Section Title Doc Link 20067770 Disease Relevance 0.58 Pain Relevance 0.53
These data suggest that prolonged therapy with PGE2 blocking agents decreases PGE2 production not only by direct inhibition of COX-2 activity, but also by down-regulating COX-2 and mPGES-1 synthesis in the cartilage.
Negative_regulation (down) of Gene_expression (synthesis) of mPGES-1 in cartilage
8) Confidence 0.35 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 18547825 Disease Relevance 0 Pain Relevance 0
These data suggest that prolonged therapy with PGE2 blocking agents decreases PGE2 production not only by direct inhibition of COX-2 activity, but also by down-regulating COX-2 and mPGES-1 synthesis in the cartilage.
Negative_regulation (regulating) of Gene_expression (synthesis) of mPGES-1 in cartilage
9) Confidence 0.35 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 18547825 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Both NSAID diminished PGE2 release and induced a decrease in COX-2 and mPGES-1 synthesis in the cartilage from OA patients and in OA chondrocytes.
Negative_regulation (decrease) of Gene_expression (synthesis) of mPGES-1 in cartilage
10) Confidence 0.35 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 18547825 Disease Relevance 0.05 Pain Relevance 0
The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase (mPGES-1).
Negative_regulation (inhibition) of Gene_expression (expression) of microsomal prostaglandin E synthase in PGE2
11) Confidence 0.29 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529823 Disease Relevance 0.28 Pain Relevance 0.20
MPGES-1 expression was not related to overall PGE2 content in tumor and colon tissue, but decreased significantly in normal tissue during indomethacin exposure.
Neg (not) Negative_regulation (decreased) of Gene_expression (expression) of MPGES-1 in colon associated with cancer
12) Confidence 0.04 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043083 Disease Relevance 1.18 Pain Relevance 0.18

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