INT134149

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.25
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
endothelial cell 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 9 99.06 Very High Very High Very High
Morphine 20 98.80 Very High Very High Very High
cytokine 15 98.40 Very High Very High Very High
metalloproteinase 1 94.32 High High
Inflammation 7 87.60 High High
Inflammatory response 2 87.56 High High
Inflammatory mediators 1 66.08 Quite High
Dismenorea 1 65.16 Quite High
opiate 2 64.84 Quite High
cINOD 2 64.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 33 99.52 Very High Very High Very High
Necrosis 1 90.12 High High
Cancer 4 89.76 High High
INFLAMMATION 9 87.60 High High
Death 2 81.56 Quite High
Endometriosis 5 79.60 Quite High
Esophageal Cancer 2 75.00 Quite High
Dermatitis 1 75.00 Quite High
Skin Cancer 1 74.64 Quite High
Dysmenorrhea 1 65.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunofluorescene of its p65 subunit revealed that pre-incubation with hCG-A strongly decreased TNF-alpha-dependent nuclear expression of NF-kappaB.
Negative_regulation (decreased) of Gene_expression (expression) of NF-kappaB
1) Confidence 0.55 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.65 Pain Relevance 0.30
Moreover, inhibition of Akt or nuclear factor-kappaB (NF-kappaB) expression by RNA interference technology also dramatically increased morphine-induced apoptosis.
Negative_regulation (inhibition) of Gene_expression (expression) of nuclear factor-kappaB associated with apoptosis and morphine
2) Confidence 0.38 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.07 Pain Relevance 0.92
Moreover, inhibition of Akt or nuclear factor-kappaB (NF-kappaB) expression by RNA interference technology also dramatically increased morphine-induced apoptosis.
Negative_regulation (inhibition) of Gene_expression (expression) of NF-kappaB associated with apoptosis and morphine
3) Confidence 0.38 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.07 Pain Relevance 0.92
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Negative_regulation (reduced) of Gene_expression (activity) of NF-kappaB associated with melanocortin 1 receptor
4) Confidence 0.36 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.34 Pain Relevance 0.87
NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.
Negative_regulation (decreased) of Gene_expression (production) of nuclear NF-kappaB protein
5) Confidence 0.35 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.83 Pain Relevance 0.13
Capsiate inhibited UVB-induced cyclooxygenase-2 (COX-2) expression, extracellular signal-related kinase 1/2 phosphorylation, nuclear translocation of NF-kappaB, and the expression of proinflammatory cytokines and potent angiogenic factors, including vascular endothelial cell growth factor and matrix metalloproteinase-2 (MMP-2) and MMP-9.
Negative_regulation (inhibited) of Gene_expression (expression) of NF-kappaB in endothelial cell associated with metalloproteinase and cytokine
6) Confidence 0.24 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.16 Pain Relevance 0.24
PTGES induction was blocked both in the presence of pharmacological NFkappaB inhibitors and following adenovirus-mediated overexpression of a dominant-negative NFkappaB pathway protein.
Negative_regulation (blocked) of Gene_expression (overexpression) of NFkappaB
7) Confidence 0.23 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.13 Pain Relevance 0.25

General Comments

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