INT13415

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Context Info
Confidence 0.70
First Reported 1986
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 58
Total Number 65
Disease Relevance 24.90
Pain Relevance 25.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
pituitary 6
plasma 4
neurons 2
brain 1
PVN 1
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 23 99.98 Very High Very High Very High
Morphine 82 99.92 Very High Very High Very High
cytokine 451 99.90 Very High Very High Very High
fluoxetine 5 99.86 Very High Very High Very High
Multiple sclerosis 35 99.84 Very High Very High Very High
narcan 21 99.84 Very High Very High Very High
cocaine 77 99.82 Very High Very High Very High
Enkephalin 38 99.78 Very High Very High Very High
Opioid 48 99.76 Very High Very High Very High
Hippocampus 136 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1536 99.98 Very High Very High Very High
Pressure And Volume Under Development 43 99.90 Very High Very High Very High
Multiple Sclerosis 132 99.84 Very High Very High Very High
Thyroid Disease 73 99.66 Very High Very High Very High
Cytomegalovirus Infection 16 99.52 Very High Very High Very High
Dyspareunia 7 99.48 Very High Very High Very High
Anxiety Disorder 35 99.44 Very High Very High Very High
INFLAMMATION 705 99.40 Very High Very High Very High
Targeted Disruption 369 99.20 Very High Very High Very High
Metastasis 4 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of nifedipine on morphine analgesic tolerance in intact and adrenalectomized (ADX) rats and on HPA activity induced by morphine.
Positive_regulation (induced) of HPA associated with analgesic, tolerance and morphine
1) Confidence 0.70 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15894073 Disease Relevance 0.07 Pain Relevance 1.31
The differential of pain on the development of tolerance to morphine analgesia are suggested to be related to genetically determined differences in stress-induced HPA activity.
Positive_regulation (induced) of HPA associated with stress, pain, tolerance, analgesia and morphine
2) Confidence 0.69 Published 1995 Journal Pain Section Abstract Doc Link 8719540 Disease Relevance 1.11 Pain Relevance 1.87
RESULTS: In outbred rats, DMCM/restraint increased both HPA activity and morphine-induced CPP, while antalarmin decreased CPP and produced a slight, but nonsignificant, decrease in corticosterone levels.
Positive_regulation (increased) of HPA
3) Confidence 0.67 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 17016707 Disease Relevance 0.07 Pain Relevance 0
Corticotropin releasing hormone (CRH) neurons located in the hypothalamus are important for HPA activation.
Positive_regulation (activation) of HPA in neurons
4) Confidence 0.63 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 15833600 Disease Relevance 0.18 Pain Relevance 0.30
Inbred female Fischer rats, which show significant stress-induced HPA activity, were used for comparison.
Positive_regulation (induced) of HPA associated with stress
5) Confidence 0.60 Published 1995 Journal Pain Section Abstract Doc Link 8719540 Disease Relevance 1.21 Pain Relevance 2.19
We also evaluated the effect of this drug on HPA activity induced by naloxone.
Positive_regulation (induced) of HPA associated with narcan
6) Confidence 0.55 Published 2008 Journal Horm Behav Section Abstract Doc Link 18177874 Disease Relevance 0.09 Pain Relevance 0.95
Naloxone also attenuated the exaggeration in stress-induced HPA activity but did not affect the increases in plasma ACTH concentration which followed adrenalectomy.
Neg (not) Positive_regulation (induced) of HPA in plasma associated with stress and narcan
7) Confidence 0.52 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3010154 Disease Relevance 0.28 Pain Relevance 0.32
The results suggest that opioid substances stimulate HPA activity by depressing the activity of the adrenergic pathways which inhibit the secretion of CRF.
Positive_regulation (stimulate) of HPA associated with opioid
8) Confidence 0.48 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2821423 Disease Relevance 0.34 Pain Relevance 0.47
No gender difference in HPA axis activation was observed in a dose-response study of cocaine-induced HPA activation in 10 day old rats.
Positive_regulation (activation) of HPA associated with cocaine
9) Confidence 0.48 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9165495 Disease Relevance 0 Pain Relevance 0.53
We examined the effect of nifedipine on morphine-induced analgesia in intact and adrenalectomized (ADX) rats and on HPA activity induced by morphine.
Positive_regulation (induced) of HPA associated with analgesia and morphine
10) Confidence 0.47 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16111739 Disease Relevance 0.08 Pain Relevance 1.10
Specifically, manipulations that increase or decrease HPA activity also increase or decrease drug intake, respectively.
Positive_regulation (increase) of HPA
11) Confidence 0.45 Published 2006 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17016707 Disease Relevance 0.15 Pain Relevance 0.07
These results indicate that clonidine given centrally stimulates the HPA activity via not only alpha-adrenergic but also histaminergic mechanisms.
Positive_regulation (stimulates) of HPA associated with clonidine
12) Confidence 0.44 Published 1993 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8241531 Disease Relevance 0.06 Pain Relevance 1.07
Taken together, the present results show that after development of adaptation or tolerance to chronic 'binge' cocaine there is an increase in HPA activity during acute cocaine withdrawal.
Positive_regulation (increase) of HPA associated with tolerance, withdrawal and cocaine
13) Confidence 0.43 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576179 Disease Relevance 0 Pain Relevance 0.85
Although the catecholamines, norepinephrine (NE) and dopamine (DA) are believed to be crucial factors in the stimulation of CRH neurons, it is not clear if they affect the cell bodies or terminals of these neurons to cause HPA activation.
Positive_regulation (activation) of HPA in neurons associated with dopamine and catecholamine
14) Confidence 0.42 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 15833600 Disease Relevance 0.15 Pain Relevance 0.31
Females also showed enhanced HPA axis activation following administration of the dopamine uptake inhibitor GBR 12909, the serotonin uptake inhibitor fluoxetine, and the norepinephrine uptake inhibitor desipramine.
Positive_regulation (activation) of HPA associated with desipramine, norepinephrine uptake inhibitor, dopamine, serotonin and fluoxetine
15) Confidence 0.41 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9165495 Disease Relevance 0 Pain Relevance 0.49
Thus, prostaglandins considerably mediate the HPA activity stimulated via central alpha 1- and alpha 2- but not beta-adrenergic receptors.
Positive_regulation (mediate) of HPA
16) Confidence 0.34 Published 1996 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9116324 Disease Relevance 0.36 Pain Relevance 0.43
Tissues from women with localized vulvodynia documented a significant increase in vestibular mast cells, subepithelial heparanase activity, and intraepithelial hyperinnervation compared with healthy women.
Positive_regulation (increase) of heparanase in mast cells associated with vaginimus
17) Confidence 0.34 Published 2008 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 18156988 Disease Relevance 0.58 Pain Relevance 0.63
Central histamine receptors do not mediate the metenkephalinamide-induced HPA stimulation.
Neg (not) Positive_regulation (mediate) of HPA
18) Confidence 0.33 Published 1995 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8527812 Disease Relevance 0 Pain Relevance 0.43
They also suggest involvement of prostaglandins and histamine of the hippocampus in the clonidine-induced HPA response.
Positive_regulation (induced) of HPA in hippocampus associated with hippocampus and clonidine
19) Confidence 0.31 Published 1996 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8877904 Disease Relevance 0 Pain Relevance 0.57
Intracerebroventricular (i.c.v.) administration of the delta-selective agonist DPDPE ([D-Pen2,D-Pen2]enkephalin) produced stimulation of HPA activity, as shown by an increase in corticosterone release.
Positive_regulation (stimulation) of HPA associated with agonist, enkephalin and intracerebroventricular
20) Confidence 0.31 Published 1994 Journal Gen. Pharmacol. Section Abstract Doc Link 7958733 Disease Relevance 0.17 Pain Relevance 0.84

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