INT13416

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 14.78
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pthlh) Golgi apparatus (Pthlh) nucleolus (Pthlh)
nucleus (Pthlh) intracellular (Pthlh) cellular_component (Pthlh)
Anatomy Link Frequency
parathyroid 12
plasma 2
neuronal 1
thyroid 1
spinal cord 1
Pthlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 2 99.60 Very High Very High Very High
agonist 4 99.22 Very High Very High Very High
cocaine 7 99.04 Very High Very High Very High
backache 10 98.76 Very High Very High Very High
qutenza 5 97.60 Very High Very High Very High
orphanin 9 96.32 Very High Very High Very High
Pain 3 95.64 Very High Very High Very High
opioid receptor 3 94.88 High High
antagonist 10 94.52 High High
Angina 1 93.88 High High
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 45 99.92 Very High Very High Very High
Hypercalcemia 34 99.90 Very High Very High Very High
Osteoporosis 10 99.88 Very High Very High Very High
Leukocytosis 1 99.72 Very High Very High Very High
Cancer 137 99.52 Very High Very High Very High
Congenital Anomalies 5 99.36 Very High Very High Very High
Skin Cancer 25 99.08 Very High Very High Very High
Low Back Pain 10 98.76 Very High Very High Very High
B-cell Lymphoma 1 98.48 Very High Very High Very High
Disease 21 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The back pain and biochemical abnormalities presented as hypercalcemia and elevated plasma levels of the parathyroid hormone-related protein (PTH-rP) that returned to normal indices with increasing BMD after weaning.
Positive_regulation (elevated) of PTH-rP in parathyroid associated with congenital anomalies, hypercalcemia and backache
1) Confidence 0.60 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 10067016 Disease Relevance 0.47 Pain Relevance 0.19
The increased circulating PTH-rP might contribute to the pregnancy-associated osteoporosis in women who probably are already osteopenic.
Positive_regulation (increased) of PTH-rP associated with osteoporosis
2) Confidence 0.60 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 10067016 Disease Relevance 0.54 Pain Relevance 0.18
Treatment with phorbol myristate acetate or 1-oleoyl-2-acetyl-sn-glycerol produced a dose-related, 2- to 4-fold increase in PTHrP secretion.
Positive_regulation (increase) of PTHrP
3) Confidence 0.47 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.13 Pain Relevance 0.19
The increased circulating PTH-rP might contribute to the pregnancy-associated osteoporosis in women who probably are already osteopenic.
Positive_regulation (increased) of PTH-rP associated with osteoporosis
4) Confidence 0.43 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 10067016 Disease Relevance 0.54 Pain Relevance 0.18
The back pain and biochemical abnormalities presented as hypercalcemia and elevated plasma levels of the parathyroid hormone-related protein (PTH-rP) that returned to normal indices with increasing BMD after weaning.
Positive_regulation (elevated) of parathyroid hormone-related protein in parathyroid associated with congenital anomalies, hypercalcemia and backache
5) Confidence 0.40 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 10067016 Disease Relevance 0.47 Pain Relevance 0.19
Pregnancy-associated osteoporosis with elevated levels of circulating parathyroid hormone-related protein: a report of two cases.
Positive_regulation (elevated) of parathyroid hormone-related protein in parathyroid associated with osteoporosis
6) Confidence 0.40 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Title Doc Link 10067016 Disease Relevance 0.47 Pain Relevance 0.19
Parathyroid hormone like hormone (PTHLH) has been previously identified as being induced in NSCLCs (Nishigaki, Ohsaki et al. 1999; Hiraki, Ueoka et al. 2002).
Positive_regulation (induced) of PTHLH in Parathyroid
7) Confidence 0.40 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717848 Disease Relevance 1.43 Pain Relevance 0
After grouping the needle and tumor biopsy array data by tumor type we confirmed that PTHLH was indeed induced, most strongly in the squamous cell carcinoma tissues (Figure 3A).
Positive_regulation (induced) of PTHLH associated with cancer and skin cancer
8) Confidence 0.40 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717848 Disease Relevance 1.38 Pain Relevance 0
Parathyroid hormone like hormone (PTHLH) has been previously identified as being induced in NSCLCs (Nishigaki, Ohsaki et al. 1999; Hiraki, Ueoka et al. 2002).
Positive_regulation (induced) of Parathyroid hormone like hormone in Parathyroid
9) Confidence 0.40 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717848 Disease Relevance 1.49 Pain Relevance 0
In these 12 patients, the serum level of parathyroid hormone-related protein (PTH-rP) was also significantly elevated.
Positive_regulation (elevated) of parathyroid hormone-related protein in parathyroid
10) Confidence 0.32 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 12729778 Disease Relevance 1.72 Pain Relevance 0
In these 12 patients, the serum level of parathyroid hormone-related protein (PTH-rP) was also significantly elevated.
Positive_regulation (elevated) of PTH-rP in parathyroid
11) Confidence 0.32 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 12729778 Disease Relevance 1.71 Pain Relevance 0
Elevation of parathyroid hormone-related protein (PTHrP) and hypercalcemia were confirmed pretreatment, and those serum levels decreased during chemotherapy for lymphoma.
Positive_regulation (Elevation) of parathyroid hormone-related protein in parathyroid associated with lymphatic system cancer and hypercalcemia
12) Confidence 0.25 Published 2006 Journal Am. J. Hematol. Section Abstract Doc Link 16680736 Disease Relevance 1.15 Pain Relevance 0.09
Serum calcium and parathyroid hormone-related protein (PTHrP) levels were extremely elevated.
Positive_regulation (elevated) of parathyroid hormone-related protein in parathyroid
13) Confidence 0.23 Published 1998 Journal Respiration Section Abstract Doc Link 9523373 Disease Relevance 0.45 Pain Relevance 0.09
Laboratory data showed blasts in the peripheral blood, hypercalcemia (corrected calcium 15.1 mg/dl) and an increased level of parathyroid hormone related-protein (PTHrP).
Positive_regulation (increased) of parathyroid hormone related-protein in parathyroid associated with hypercalcemia
14) Confidence 0.21 Published 1995 Journal Rinsho Ketsueki Section Abstract Doc Link 7715075 Disease Relevance 0.52 Pain Relevance 0.10
Laboratory data showed blasts in the peripheral blood, hypercalcemia (corrected calcium 15.1 mg/dl) and an increased level of parathyroid hormone related-protein (PTHrP).
Positive_regulation (level) of parathyroid hormone related-protein in parathyroid associated with hypercalcemia
15) Confidence 0.14 Published 1995 Journal Rinsho Ketsueki Section Abstract Doc Link 7715075 Disease Relevance 0.52 Pain Relevance 0.10
Evidence for an excitatory action of the benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents.

(1) The stimulation of adrenocorticotrophic hormone (ACTH) release by FG 7142 was found to be 50% inhibited in capsaicin-desensitized rats indicating that the excitatory effect of this inverse benzodiazepine agonist is partly mediated through capsaicin-sensitive afferents. (2) The in vitro release of substance P from spinal cord slices was stimulated in a tetrodotoxin-resistant manner by FG 7142.

Positive_regulation (stimulation) of adrenocorticotrophic hormone in spinal cord associated with tetrodotoxin, c fibre, qutenza, agonist, spinal cord and substance p
16) Confidence 0.09 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2478895 Disease Relevance 0 Pain Relevance 0.87
High levels of serum parathyroid hormone-related peptide (PTHrP) and granulocyte colony stimulating factor (G-CSF) were detected.
Positive_regulation (levels) of parathyroid hormone-related peptide in parathyroid
17) Confidence 0.06 Published 2008 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 18939454 Disease Relevance 1.10 Pain Relevance 0.06
The neuronal changes in SA animals were correlated with elevated adrenocorticotrophic hormone (ACTH) (64% and 104%) and glucocorticoid production (198% and 79%) compared with YH and YS groups, respectively.
Positive_regulation (elevated) of adrenocorticotrophic hormone in neuronal
18) Confidence 0.03 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19467321 Disease Relevance 0.14 Pain Relevance 0.32
We found that, at 30 min post-i.c.v. injection, N/OFQ dose-dependently increased plasma adrenocorticotrophin hormone and corticosterone compared with the vehicle-injected controls.
Positive_regulation (increased) of adrenocorticotrophin hormone in plasma
19) Confidence 0.03 Published 2006 Journal Neuroscience Section Abstract Doc Link 16784820 Disease Relevance 0 Pain Relevance 0.52
The acute administration of cocaine (5-20 mg/kg) to rats produced a dose-dependent elevation in both serum corticosterone and plasma adrenocorticotrophic hormone (ACTH).
Positive_regulation (elevation) of adrenocorticotrophic hormone in plasma associated with cocaine
20) Confidence 0.03 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1671094 Disease Relevance 0 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox