INT134167

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ADRA2A, APLP1) plasma membrane (ADRA2A, APLP1) small molecule metabolic process (ADRA2A)
Golgi apparatus (APLP1) extracellular matrix organization (APLP1) signal transducer activity (ADRA2A)
ADRA2A (Homo sapiens)
APLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 8 99.20 Very High Very High Very High
Analgesic 2 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 100.00 Very High Very High Very High
Disease 2 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agonist treatment tended to increase the amount of alpha2A-adrenergic receptor associated with APLP1 while coimmunoprecipitations were not affected by the state of receptor phosphorylation or cotransfection of arrestin-3.
alpha2A-adrenergic Binding (associated) of APLP1 associated with agonist
1) Confidence 0.09 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16531006 Disease Relevance 0.31 Pain Relevance 0.17
Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase.
alpha2A-adrenergic Binding (Interaction) of amyloid precursor like protein 1 associated with alzheimer's dementia and agonist
2) Confidence 0.09 Published 2006 Journal Cell. Signal. Section Title Doc Link 16531006 Disease Relevance 0.33 Pain Relevance 0.22

General Comments

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