INT134173

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.41
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (APLP1) cell adhesion (APLP1) Golgi apparatus (APLP1)
plasma membrane (APLP1) extracellular matrix organization (APLP1) cytoplasm (APLP1)
Anatomy Link Frequency
B lymphocyte 1
APLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 12 99.84 Very High Very High Very High
Analgesic 3 94.12 High High
cva 5 89.72 High High
Central nervous system 16 24.40 Low Low
Fibrositis 24 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
spastic colon 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 23 100.00 Very High Very High Very High
Disease 17 100.00 Very High Very High Very High
Syndrome 39 99.16 Very High Very High Very High
Amyloidosis 9 90.40 High High
Cv General 3 Under Development 3 89.72 High High
Chronic Fatigue Syndrome 184 83.20 Quite High
Apoptosis 3 69.04 Quite High
Cerebral Amyloid Angiopathy 11 61.24 Quite High
Dementia 2 56.80 Quite High
Hemorrhage 3 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coimmunoprecipitations of transiently transfected cells with epitope-tagged APLP1 and alpha2-adrenergic receptors confirmed the interaction.
APLP1 Binding (interaction) of
1) Confidence 0.37 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16531006 Disease Relevance 0.32 Pain Relevance 0.18
This screen identified the amyloid precursor like protein 1 (APLP1), a homologue of the beta-amyloid precursor protein involved in Alzheimer's disease, as alpha2A-adrenergic receptor-binding protein.
amyloid precursor like protein 1 Binding (binding) of associated with alzheimer's dementia and disease
2) Confidence 0.36 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16531006 Disease Relevance 0.38 Pain Relevance 0.20
Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase.
amyloid precursor like protein 1 Binding (Interaction) of associated with alzheimer's dementia and agonist
3) Confidence 0.36 Published 2006 Journal Cell. Signal. Section Title Doc Link 16531006 Disease Relevance 0.33 Pain Relevance 0.22
light chains are relatively unstable, have a tendency to unfold and polymerize [70], and have been associated with APLP1 in an intracerebral syndrome [71], and systemic amyloid syndromes with and without B lymphocyte dyscrasias [72].
APLP1 Binding (associated) of in B lymphocyte associated with syndrome and alzheimer's dementia
4) Confidence 0.29 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.39 Pain Relevance 0.07

General Comments

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