INT134174

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (APLP1) cell adhesion (APLP1) Golgi apparatus (APLP1)
plasma membrane (APLP1) extracellular matrix organization (APLP1) cytoplasm (APLP1)
Anatomy Link Frequency
cleavage 1
APLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 84.00 Quite High
cINOD 1 75.00 Quite High
Glutamate 1 57.60 Quite High
Analgesic 1 44.12 Quite Low
Fibrositis 24 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
spastic colon 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 21 100.00 Very High Very High Very High
Chronic Fatigue Syndrome 184 99.56 Very High Very High Very High
Disease 16 97.54 Very High Very High Very High
Syndrome 39 5.00 Very Low Very Low Very Low
Sleep Disorders 24 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Cerebral Amyloid Angiopathy 11 5.00 Very Low Very Low Very Low
Fatigue 11 5.00 Very Low Very Low Very Low
Amyloidosis 9 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, cotransfection of alpha2A-adrenergic receptor and APLP1 into HEK293 cells significantly increased norepinephrine mediated inhibition of adenylate cyclase activity.
Gene_expression (cotransfection) of APLP1
1) Confidence 0.77 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16531006 Disease Relevance 0.26 Pain Relevance 0.12
APLP1, BEHAB, orosomucoid 1 (ORM1, ?
Gene_expression (orosomucoid) of APLP1
2) Confidence 0.55 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.05 Pain Relevance 0.03
Inhibition of gamma-secretase cleavage of the amyloid precursor protein (APP) is a prime target for the development of therapeutics for treating Alzheimer's disease; however, complete inhibition of this activity would also impair the processing of many other proteins, including the APP homologues, amyloid precursor-like protein (APLP) 1 and 2.
Gene_expression (homologues) of APLP in cleavage associated with alzheimer's dementia and disease
3) Confidence 0.06 Published 2009 Journal Biochemistry Section Abstract Doc Link 19821615 Disease Relevance 0.44 Pain Relevance 0.07

General Comments

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