INT134176

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADRA2A) small molecule metabolic process (ADRA2A) plasma membrane (ADRA2A)
cytoplasm (ADRA2A) signal transducer activity (ADRA2A)
Anatomy Link Frequency
dendrites 1
sympathetic 1
ADRA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 12 96.40 Very High Very High Very High
agonist 19 84.00 Quite High
Catecholamine 3 75.36 Quite High
Catechol-O-methyltransferase 17 50.32 Quite High
Dopamine 81 46.24 Quite Low
Analgesic 1 44.12 Quite Low
nMDA receptor 3 14.64 Low Low
Pyramidal cell 12 9.32 Low Low
Cannabinoid receptor 9 5.00 Very Low Very Low Very Low
Nucleus accumbens 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 13 90.68 High High
Pressure And Volume Under Development 27 89.72 High High
Hyperandrogenism 6 89.16 High High
Stress 22 88.80 High High
Metabolic Syndrome 14 88.44 High High
Metabolic Disorder 2 86.16 High High
Polycystic Ovary Syndrome 33 84.28 Quite High
Alzheimer's Dementia 3 75.00 Quite High
Disease 3 64.92 Quite High
Attention Deficit Hyperactivity Disorder 40 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our objectives in this study were (1) to estimate sympathetic-adrenal medullary (SAM) activity by measuring mean systolic blood pressure (MSAP) in rats with estradiol valerate (EV)-induced PCO; (2) to estimate alpha1a and alpha2a adrenoceptor expression in a brain area thought to mediate central effects on MSAP regulation and in the adrenal medulla; (3) to assess hypothalamic-pituitary-adrenal (HPA) axis regulation by measuring adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels in response to novel-environment stress; and (4) to measure abdominal obesity, sex steroids, and insulin sensitivity.


Gene_expression (expression) of alpha2a adrenoceptor in sympathetic associated with stress, medulla and metabolic syndrome
1) Confidence 0.58 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1236959 Disease Relevance 0.99 Pain Relevance 0.07
HEK293 cells have been reported to possess mRNA for a number of receptors that were not found to be expressed at statistically significant levels in our study: 5HT1D, 5HT6, 5HT7, ADRA2(a-c), ADRAB2, AGTR1, BDKRB2, DRD2, GPR1, GPR161, GRM4, P2YR2 and SSTR2 [17,26,46-50].
Gene_expression (expressed) of ADRA2
2) Confidence 0.21 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0
Furthermore, cotransfection of alpha2A-adrenergic receptor and APLP1 into HEK293 cells significantly increased norepinephrine mediated inhibition of adenylate cyclase activity.
Gene_expression (cotransfection) of alpha2A-adrenergic
3) Confidence 0.16 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16531006 Disease Relevance 0.26 Pain Relevance 0.12
They are localised on distal pyramidal dendrites and according to the authors, are co-expressed with the alpha-2A adrenoreceptor, thus providing a potent substratum for functional integration in the primate PFC.
Gene_expression (expressed) of alpha-2A adrenoreceptor in dendrites
4) Confidence 0.10 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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