INT13418

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Context Info
Confidence 0.54
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.55
Pain Relevance 5.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Lpp) nucleus (Lpp) molecular_function (Lpp)
cellular_component (Lpp) biological_process (Lpp) cytoplasm (Lpp)
Anatomy Link Frequency
spikes 1
synapses 1
Lpp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 68 100.00 Very High Very High Very High
Morphine 42 99.50 Very High Very High Very High
Endogenous opioid 1 98.52 Very High Very High Very High
nMDA receptor antagonist 1 93.24 High High
narcan 4 91.92 High High
Opioid 4 90.32 High High
analgesia 1 86.84 High High
anesthesia 3 85.96 High High
MU agonist 1 80.00 Quite High
antagonist 6 73.40 Quite High
Disease Link Frequency Relevance Heat
Sneezing 2 79.20 Quite High
Decapitation 4 72.00 Quite High
Cough 1 71.20 Quite High
Stress Incontinence 32 66.52 Quite High
Injury 4 5.00 Very Low Very Low Very Low
Graft Vs Host Disease 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Spinal Cord Injury 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Population spikes (PS), evoked by stimulation of the LPP, was recorded from DG region.
Positive_regulation (stimulation) of LPP in spikes
1) Confidence 0.54 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20451544 Disease Relevance 0 Pain Relevance 1.23
Prenatal morphine exposure suppresses LTP induction in the LPP during proestrus.
Positive_regulation (induction) of LPP associated with long-term potentiation and morphine
2) Confidence 0.36 Published 2005 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16165340 Disease Relevance 0.07 Pain Relevance 0.55
Data indicate that the induction and maintenance of LTP in the LPP in hippocampal slices from female rats is multifactorial: ovarian steroids and functionality of glucocorticoid receptors cooperation are necessary for induction and maintenance of the LTP, prenatal morphine exposure interferes with this process possibly by its long-term effects on synaptic plasticity.
Positive_regulation (maintenance) of LPP associated with long-term potentiation and morphine
3) Confidence 0.36 Published 2005 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16165340 Disease Relevance 0.06 Pain Relevance 1.02
Data indicate that the induction and maintenance of LTP in the LPP in hippocampal slices from female rats is multifactorial: ovarian steroids and functionality of glucocorticoid receptors cooperation are necessary for induction and maintenance of the LTP, prenatal morphine exposure interferes with this process possibly by its long-term effects on synaptic plasticity.
Positive_regulation (induction) of LPP associated with long-term potentiation and morphine
4) Confidence 0.36 Published 2005 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16165340 Disease Relevance 0.06 Pain Relevance 1.03
Thus, prenatal morphine exposure suppresses the induction of LTP in the LPP, except during diestrus.
Positive_regulation (induction) of LPP associated with long-term potentiation and morphine
5) Confidence 0.36 Published 2005 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16165340 Disease Relevance 0.07 Pain Relevance 1.11
Both peak pressure and increase in pressure during LPP (43.4 +/- 3.6 and 33.1 +/- 3.8 cm H2O, respectively) were significantly higher than pressures during both SV (30.4 +/- 3.8 and 19.3 +/- 3.4 cm H2O, respectively) and sneeze (9.5 +/- 0.7 and 2.6 +/- 0.5 cm H2O, respectively).
Positive_regulation (increase) of LPP
6) Confidence 0.26 Published 2003 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 15176326 Disease Relevance 0.22 Pain Relevance 0.09
But, the LPP values were significantly increased in the experimental group at 4 weeks while the control group did not show significant change in LPP value (mean LPP for control group (n=14): 65.02±22.09 mmHg, for the experimental group (n=19): 91.75±18.99 mmHg, P=0.001, t=-3.728, within 95% validity interval).


Positive_regulation (increased) of LPP
7) Confidence 0.23 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2858822 Disease Relevance 0.06 Pain Relevance 0
These findings suggest that endogenous opioids released during high frequency stimulation play an important role in the induction of LTP at the LPP synapses.
Positive_regulation (induction) of LPP in synapses associated with endogenous opioid and long-term potentiation
8) Confidence 0.20 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1671096 Disease Relevance 0 Pain Relevance 0.82

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