INT134207

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 6
Speculated 6
Reported most in Body
Documents 56
Total Number 81
Disease Relevance 31.97
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
smooth muscle cells 11
vessels 5
extracellular matrix 5
adventitial cells 3
brain 2
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 84 98.44 Very High Very High Very High
Inflammation 92 94.24 High High
cytokine 46 92.96 High High
Central nervous system 18 77.44 Quite High
dorsal root ganglion 19 70.36 Quite High
tetrodotoxin 3 64.80 Quite High
Versed 46 51.60 Quite High
ketamine 22 21.24 Low Low
anesthesia 32 20.68 Low Low
Analgesic 47 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1128 100.00 Very High Very High Very High
Glioma 1040 99.68 Very High Very High Very High
Cancer 1562 99.54 Very High Very High Very High
Metastasis 228 99.32 Very High Very High Very High
Neointima 414 99.20 Very High Very High Very High
Apoptosis 266 99.04 Very High Very High Very High
Polycystic Kidney Disease 124 98.72 Very High Very High Very High
Malignant Neoplastic Disease 100 98.72 Very High Very High Very High
Adenocarcinoma 20 98.60 Very High Very High Very High
Hyperplasia 119 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that smooth muscle cells cultured on fibronectin substrate highly expressed FAK and FAK (pY397), to a lesser amount on Laminin substrate and very little inside a Matrigel basement membrane matrix (Fig. 2a–f, Table 3).Fig. 2Confocal micrographs of FAK and FAK(pY397) immunostaining in smooth muscle cells cultured on different substances.
Gene_expression (expressed) of FAK in smooth muscle cells
1) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
We tested the possible role of the components of the basement membrane in regulating the expression of FAK and FAK (pY397) in smooth muscle cells.
Gene_expression (expression) of FAK in smooth muscle cells
2) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
FAK(pY397) was mainly detected in endothelial cells.
Gene_expression (detected) of FAK in endothelial cells
3) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
Factors mediating expression of FAK and integrins 5?
Gene_expression (expression) of FAK
4) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.60 Pain Relevance 0.04
We tested the possible role of the components of the basement membrane in regulating the expression of FAK and FAK (pY397) in smooth muscle cells.
Gene_expression (expression) of FAK in smooth muscle cells
5) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
In normal arterial vessels, endothelial cells expressed FAK, but the majority of the media SMCs and adventitial cells only weakly expressed FAK.
Gene_expression (expressed) of FAK in adventitial cells
6) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
Expression of FAK and FAK(pY397) in vivo and in vitro
Gene_expression (Expression) of FAK
7) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
Expression of FAK and FAK(pY397) in vivo and in vitro
Gene_expression (Expression) of FAK
8) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
In normal arterial vessels, endothelial cells expressed FAK, but the majority of the media SMCs and adventitial cells only weakly expressed FAK.
Gene_expression (expressed) of FAK in adventitial cells
9) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
The immunostaining of FAK and FAK(pY397) in serial sections revealed that increased expression of FAK was accompanied by an increase of expression of FAK(pY397) Fig. 1d–e).Fig. 1Confocal micrographs of FAK and FAK(pY397) immunostaining in normal (NV), control (only ligation) (CLV), and AV-shunt (AV-S) collateral vessels. a–d: FAK; e: FAK(pY397). a: NV; b: CLV, c, d and e: AV-S.
Gene_expression (expression) of FAK in vessels
10) Confidence 0.73 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
FAK was highly expressed in the control tumor brains as compared to hUCBSC-treated brain sections, which showed high expression of CD81 (Figure 5B).
Gene_expression (expressed) of FAK in brain associated with cancer
11) Confidence 0.72 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.83 Pain Relevance 0
In cancer cells, attenuation of FAK expression induces detachment and apoptosis [18] suggesting that a FAK-dependent signal is required for tumor cell growth.
Gene_expression (expression) of FAK associated with cancer and apoptosis
12) Confidence 0.72 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.66 Pain Relevance 0
Inverted repeat sequences were synthesized for FAK.
Gene_expression (synthesized) of FAK
13) Confidence 0.72 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.32 Pain Relevance 0
However, the causal role of FAK in tumor development combined with reports that increased FAK expression is associated with poor clinical outcome [8,9], indicate that FAK might be a useful therapeutic target [7,10].
Gene_expression (expression) of FAK associated with cancer
14) Confidence 0.72 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.59 Pain Relevance 0
We also checked the expression of FAK in the control tumor and hUCBSC-treated tumor sections.
Gene_expression (expression) of FAK associated with cancer
15) Confidence 0.72 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.74 Pain Relevance 0
FAK is overexpressed in invasive and metastatic tumors [16], and the FAK gene is also amplified in many types of tumors [17] suggesting a role for FAK in adhesion or survival in tumor cells.
Gene_expression (overexpressed) of FAK associated with cancer, adhesions and metastasis
16) Confidence 0.72 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.65 Pain Relevance 0
To test the importance of FAK signaling in these processes, we analyzed cells expressing a dominant negative form of FAK (dnFAK).
Neg (negative) Spec (analyzed) Gene_expression (expressing) of dnFAK
17) Confidence 0.67 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16533505 Disease Relevance 0.30 Pain Relevance 0.06
When cells expressing dnFAK were induced to differentiate, both costamerogenesis and myofibrillogenesis were disrupted although the expression of constituent proteins was not inhibited.
Gene_expression (expressing) of dnFAK
18) Confidence 0.67 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16533505 Disease Relevance 0.30 Pain Relevance 0.06
To test the importance of FAK signaling in these processes, we analyzed cells expressing a dominant negative form of FAK (dnFAK).
Neg (negative) Spec (analyzed) Gene_expression (expressing) of FAK
19) Confidence 0.67 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16533505 Disease Relevance 0.30 Pain Relevance 0.06
We found that smooth muscle cells cultured on fibronectin substrate highly expressed FAK and FAK (pY397), to a lesser amount on Laminin substrate and very little inside a Matrigel basement membrane matrix (Fig. 2a–f, Table 3).Fig. 2Confocal micrographs of FAK and FAK(pY397) immunostaining in smooth muscle cells cultured on different substances.
Gene_expression (expressed) of FAK in smooth muscle cells
20) Confidence 0.63 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0

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