INT134208

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 32
Disease Relevance 23.59
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
brains 5
blood vessels 3
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 30 88.96 High High
tetrodotoxin 2 81.44 Quite High
Bioavailability 6 79.80 Quite High
antagonist 18 73.76 Quite High
cytokine 19 73.24 Quite High
Hyperalgesia 1 63.12 Quite High
Peripheral nerve injury 1 61.20 Quite High
chemokine 42 50.00 Quite Low
Mechanotransduction 12 50.00 Quite Low
fortral 12 45.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 419 100.00 Very High Very High Very High
Cancer 1706 99.64 Very High Very High Very High
Metastasis 330 99.24 Very High Very High Very High
Polycystic Kidney Disease 62 98.90 Very High Very High Very High
Glioma 794 98.52 Very High Very High Very High
Apoptosis 334 97.96 Very High Very High Very High
Glioblastoma 184 97.92 Very High Very High Very High
Targeted Disruption 37 97.60 Very High Very High Very High
Adenocarcinoma 21 96.84 Very High Very High Very High
Melanoma 189 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, inhibiting FAK activity by reducing FAK levels using an siRNA approach also resulted in an inhibition of costamerogenesis and myofibrillogenesis.
Negative_regulation (reducing) of FAK
1) Confidence 0.58 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16533505 Disease Relevance 0.27 Pain Relevance 0.08
To evaluate the mechanism of action of hUCBSC, we repeated the experiment with FAK inhibitor and siRNA to FAK (siFAK).
Negative_regulation (inhibitor) of FAK
2) Confidence 0.55 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.72 Pain Relevance 0
This TM-mediated decrease in MMP-2 production could be due to its inhibitory effect on FAK as it has been shown that blocking of FAK activity by either dominant negative mutants or antisence treatment significantly decreases MMP expression [44,45].
Negative_regulation (effect) of FAK
3) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.94 Pain Relevance 0.04
Likewise, inhibiting FAK activity by reducing FAK levels using an siRNA approach also resulted in an inhibition of costamerogenesis and myofibrillogenesis.
Negative_regulation (inhibiting) of FAK
4) Confidence 0.43 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16533505 Disease Relevance 0.27 Pain Relevance 0.08
FAK inactivation
Negative_regulation (inactivation) of FAK
5) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849965 Disease Relevance 0.42 Pain Relevance 0
Reduction in angiogenesis was associated with downregulation of FAK and integrin ?
Negative_regulation (downregulation) of FAK
6) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Abstract Doc Link PMC3006022 Disease Relevance 0.84 Pain Relevance 0
In the present study, we also observed that downregulation of FAK resulted in decreased tumor growth in hUCBSC-treated tumors in mice brains.
Negative_regulation (downregulation) of FAK in brains associated with cancer
7) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.90 Pain Relevance 0
Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma

Angiogenesis involves the formation of new blood vessels by rerouting or remodeling existing ones and is believed to be the primary method of vessel formation in gliomas.

Negative_regulation (Downregulation) of FAK in blood vessels associated with glioblastoma, glioma and adhesions
8) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Title Doc Link PMC3006022 Disease Relevance 0.82 Pain Relevance 0
To evaluate the mechanism by which angiogenesis is inhibited in the nude mice tumor brains, we analyzed the tissue lysates by immunoblot analysis and observed that FAK was downregulated in tissue lysates of hUCBSC treatments.
Negative_regulation (downregulated) of FAK in brains associated with cancer
9) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.83 Pain Relevance 0
Theseresults confirm that downregulation of FAK in mice tumor brains induces the downregulation of integrins as well as growth factors necessary for angiogenesis.
Negative_regulation (downregulation) of FAK in brains associated with cancer
10) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.72 Pain Relevance 0
In hUCBSC-treated mice brains, downregulation of FAK and pFAK at Tyr397 was significant (Figure 6B).
Negative_regulation (downregulation) of FAK in brains
11) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.71 Pain Relevance 0
The activation of endogenous EphA2 by ephrin-A1 was also found to suppress the activity of FAK and integrins [24], and thus inhibits integrin-mediated cell migration.
Negative_regulation (suppress) of FAK
12) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.72 Pain Relevance 0
These results confirm that hUCBSC are acting by a mechanism similar to FAK inhibitor or siFAK.
Negative_regulation (inhibitor) of FAK
13) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.66 Pain Relevance 0
This proves our hypothesis that hUCBSC probably downregulate FAK in order to inhibit angiogenesis of glioma cells.
Negative_regulation (downregulate) of FAK associated with glioma
14) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.70 Pain Relevance 0
In hUCBSC-treated mice brains, downregulation of FAK and pFAK at Tyr397 was significant (Figure 6B).
Negative_regulation (downregulation) of pFAK in brains
15) Confidence 0.35 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.71 Pain Relevance 0
Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma

Angiogenesis involves the formation of new blood vessels by rerouting or remodeling existing ones and is believed to be the primary method of vessel formation in gliomas.

Negative_regulation (Downregulation) of Adhesion Kinase in blood vessels associated with glioblastoma, glioma and adhesions
16) Confidence 0.35 Published 2010 Journal Aging (Albany NY) Section Title Doc Link PMC3006022 Disease Relevance 0.81 Pain Relevance 0
Out of all these phospho-forms of FAK, only pFAK (Tyr397) was significantly downregulated in hUCBSC treatments with no significant change in other phospho forms.
Negative_regulation (downregulated) of pFAK
17) Confidence 0.35 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.63 Pain Relevance 0
These results confirm that hUCBSC are acting by a mechanism similar to FAK inhibitor or siFAK.
Negative_regulation (inhibitor) of siFAK
18) Confidence 0.35 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.66 Pain Relevance 0
This TM-mediated decrease in MMP-2 production could be due to its inhibitory effect on FAK as it has been shown that blocking of FAK activity by either dominant negative mutants or antisence treatment significantly decreases MMP expression [44,45].
Negative_regulation (blocking) of FAK
19) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.96 Pain Relevance 0.04
Our results suggest that TM treatment significantly inhibits HNSCC metastasis by decreasing tumor cell motility by inhibiting lysyl oxidase and focal adhesion kinase.
Negative_regulation (inhibiting) of adhesion kinase associated with cancer, adhesions and metastasis
20) Confidence 0.28 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.33 Pain Relevance 0.08

General Comments

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