INT134212

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2009
Negated 0
Speculated 4
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 2.89
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRH, POMC) signal transduction (CRH, POMC) extracellular region (CRH, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
Anatomy Link Frequency
autonomic 2
CRH (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 98.32 Very High Very High Very High
Pain 40 98.08 Very High Very High Very High
Neurotransmitter 4 97.80 Very High Very High Very High
narcan 16 83.60 Quite High
medulla 4 80.56 Quite High
Locus ceruleus 2 79.68 Quite High
amygdala 2 79.20 Quite High
Spinal cord 2 78.00 Quite High
Hippocampus 6 76.04 Quite High
Analgesic 4 73.76 Quite High
Disease Link Frequency Relevance Heat
Pain 36 98.08 Very High Very High Very High
Stress 114 92.32 High High
Anxiety Disorder 12 77.16 Quite High
Urological Neuroanatomy 2 70.60 Quite High
Injury 10 61.12 Quite High
Disease 46 55.80 Quite High
Increased Venous Pressure Under Development 12 51.04 Quite High
Infection 4 48.76 Quite Low
Herpes Simplex Virus Infection 4 48.36 Quite Low
Central Serous Chorioretinopathy 8 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were examined.
CRH Spec (examined) Regulation (effects) of Spec (examined) Localization (release) of ACTH associated with pain
1) Confidence 0.47 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16534240 Disease Relevance 0.38 Pain Relevance 0.51
In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were examined.
CRH Spec (examined) Regulation (effects) of Spec (examined) Localization (release) of beta-endorphin associated with pain
2) Confidence 0.47 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16534240 Disease Relevance 0.39 Pain Relevance 0.53
In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were examined.
CRH Spec (examined) Regulation (effects) of Spec (examined) Localization (release) of beta-lipotropin associated with pain
3) Confidence 0.47 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16534240 Disease Relevance 0.38 Pain Relevance 0.52
In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were examined.
CRH Spec (examined) Regulation (effects) of Spec (examined) Localization (release) of adrenocorticotropic hormone associated with pain
4) Confidence 0.47 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16534240 Disease Relevance 0.37 Pain Relevance 0.51
In addition to regulation of ACTH release, CRH flows diffusely throughout the brain, and serves as a neurotransmitter that mediates sympathetic arousal, providing an important link between the adrenocortical and autonomic branches of the stress response [24].
CRH Regulation (regulation) of Localization (release) of ACTH in autonomic associated with stress and neurotransmitter
5) Confidence 0.06 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 1.37 Pain Relevance 0.83

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