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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
blood 2
bowel 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 28 99.88 Very High Very High Very High
Versed 17 96.96 Very High Very High Very High
withdrawal 20 87.72 High High
ketamine 2 85.68 High High
cytokine 15 83.60 Quite High
depression 2 75.84 Quite High
Inflammatory mediators 4 75.00 Quite High
Morphine 31 70.96 Quite High
anesthesia 4 66.04 Quite High
isoflurane 2 65.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.88 Very High Very High Very High
Sepsis 17 92.64 High High
Depression 2 75.84 Quite High
Obesity 38 73.20 Quite High
Infection 78 72.56 Quite High
Gastric Motility Disorder 1 62.04 Quite High
Hepatitis C Virus Infection 3 61.68 Quite High
Hepatitis 2 55.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 49.52 Quite Low
Injury 6 26.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammatory mRNA expressions for small bowel IL-6 and MCP-1 were significantly reduced after biliverdin treatment in CLP-induced septic animals compared with untreated septic animals.
Negative_regulation (reduced) of Transcription (expressions) of IL-6 in bowel associated with inflammation
1) Confidence 0.25 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16537973 Disease Relevance 0.75 Pain Relevance 0.37
Relative mRNA expression of ICAM-1, MCP-1, IL-6, and P-selectin was determined using predeveloped assays for real-time PCR (Applied Biosystems, Foster City, CA).
Spec (determined) Negative_regulation (determined) of Spec (determined) Transcription (expression) of IL-6
2) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.18 Pain Relevance 0.06
in vitro and suppresses the expression of IL-6 mRNA in blood monoclear cells [106].
Negative_regulation (suppresses) of Transcription (expression) of IL-6 in blood
3) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.46 Pain Relevance 0.57

General Comments

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