INT134290

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 19
Disease Relevance 3.06
Pain Relevance 6.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PLD2) plasma membrane (PLD2) nucleus (PLD2)
cytoskeleton organization (PLD2)
Anatomy Link Frequency
liver 2
colon 2
stomach 2
embryonic kidney 2
PLD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 30 99.80 Very High Very High Very High
Enkephalin 3 99.62 Very High Very High Very High
opioid receptor 84 99.52 Very High Very High Very High
Morphine 6 98.74 Very High Very High Very High
tolerance 12 97.04 Very High Very High Very High
agonist 37 95.28 Very High Very High Very High
Cannabinoid receptor 3 83.92 Quite High
narcan 3 25.00 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 240 99.32 Very High Very High Very High
Colon Cancer 330 92.84 High High
Breast Cancer 40 85.08 High High
Metastasis 20 81.64 Quite High
Familial Adenomatous Polyposis 30 63.20 Quite High
Pathologic Processes 10 46.68 Quite Low
Sarcoma 10 5.00 Very Low Very Low Very Low
Glioma 10 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further demonstrated that, in human embryonic kidney (HEK) 293 cells co-expressing MOR1 and PLD2, treatment with (D-Ala2, Me Phe4, Glyol5)enkephalin (DAMGO) led to an increase in PLD2 activity and an induction of receptor endocytosis, whereas morphine, which does not induce opioid receptor endocytosis, failed to activate PLD2.
Positive_regulation (increase) of PLD2 in embryonic kidney associated with opioid receptor, enkephalin and morphine
1) Confidence 0.68 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.60
Analogously, opioid-mediated activation of PLD2 is blocked in the presence of dominant negative ARF6 mutants.
Positive_regulation (activation) of PLD2 associated with opioid
2) Confidence 0.67 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19666113 Disease Relevance 0 Pain Relevance 0.92
ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.
Positive_regulation (activation) of phospholipase D2 associated with opioid receptor
3) Confidence 0.67 Published 2009 Journal Cell. Signal. Section Title Doc Link 19666113 Disease Relevance 0 Pain Relevance 0.74
In the present study, Wnt3a and mimicking of Wnt signaling through LiCl and BIO resulted in induction of both PLD1 and PLD2 in a variety of cancer cells.
Positive_regulation (induction) of PLD2 associated with cancer
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.69 Pain Relevance 0
We further demonstrated that, in human embryonic kidney (HEK) 293 cells co-expressing MOR1 and PLD2, treatment with (D-Ala2, Me Phe4, Glyol5)enkephalin (DAMGO) led to an increase in PLD2 activity and an induction of receptor endocytosis, whereas morphine, which does not induce opioid receptor endocytosis, failed to activate PLD2.
Neg (failed) Positive_regulation (activate) of PLD2 in embryonic kidney associated with opioid receptor, enkephalin and morphine
5) Confidence 0.49 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.65
It has been further demonstrated, that the opioid-mediated and ADP-ribosylation factor (ARF)-dependent activation of phospholipase D2 (PLD2) is a prerequisite for MOPr endocytosis.
Positive_regulation (activation) of PLD2 associated with opioid receptor and opioid
6) Confidence 0.48 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19666113 Disease Relevance 0 Pain Relevance 0.62
It has been further demonstrated, that the opioid-mediated and ADP-ribosylation factor (ARF)-dependent activation of phospholipase D2 (PLD2) is a prerequisite for MOPr endocytosis.
Positive_regulation (activation) of phospholipase D2 associated with opioid receptor and opioid
7) Confidence 0.48 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19666113 Disease Relevance 0 Pain Relevance 0.62
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Positive_regulation (activation) of PLD2
8) Confidence 0.46 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.79
In this study, we investigated which particular ARF protein is involved in opioid-mediated PLD2 activation and what are the mechanisms of ARF function in MOPr trafficking and signaling.
Positive_regulation (activation) of PLD2 associated with opioid receptor and opioid
9) Confidence 0.45 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19666113 Disease Relevance 0 Pain Relevance 0.73
Together, these results provide evidence that ARF6 protein regulates MOPr trafficking and signaling via PLD2 activation and hence affects the development of opioid receptor desensitization and tolerance.
Positive_regulation (activation) of PLD2 associated with tolerance and opioid receptor
10) Confidence 0.45 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19666113 Disease Relevance 0 Pain Relevance 0.74
Moreover, both PLD1 and PLD2 were highly induced in colon, liver and stomach tissues of mice after injection of LiCl, a Wnt mimetic.
Positive_regulation (induced) of PLD2 in stomach
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920823 Disease Relevance 0.31 Pain Relevance 0
-catenin, enhanced transcriptional activation of both PLD1 and PLD2.
Positive_regulation (activation) of PLD2
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0
Additionally, Wnt and its mimetics significantly enhanced the promoter activity of both PLD1 and PLD2 (Figure 1D); Wnt3a accompanied a significant increase in gene expression from a TCF/LEF specific luciferase reporter plasmid (TOPflash) used as a control.
Positive_regulation (enhanced) of PLD2
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.41 Pain Relevance 0.04
The polyclonal anti-PLD antibody that recognizes both PLD1 and PLD2 was generated as previously described [18].


Positive_regulation (generated) of PLD2
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0
As analyzed by immunoprecipitation and immunoblot, LiCl increased protein levels of both PLD1 and PLD2 in colon, stomach, and liver tissues (Figure 2A).
Positive_regulation (increased) of PLD2 in colon
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.34 Pain Relevance 0
Moreover, both PLD1 and PLD2 were highly induced in colon, liver and stomach tissues of mice after injection of LiCl, a Wnt mimetic.
Positive_regulation (induced) of PLD2 in liver
16) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920823 Disease Relevance 0.31 Pain Relevance 0
Moreover, both PLD1 and PLD2 were highly induced in colon, liver and stomach tissues of mice after injection of LiCl, a Wnt mimetic.
Positive_regulation (induced) of PLD2 in colon
17) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920823 Disease Relevance 0.31 Pain Relevance 0
As analyzed by immunoprecipitation and immunoblot, LiCl increased protein levels of both PLD1 and PLD2 in colon, stomach, and liver tissues (Figure 2A).
Positive_regulation (increased) of PLD2 in stomach
18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.34 Pain Relevance 0
As analyzed by immunoprecipitation and immunoblot, LiCl increased protein levels of both PLD1 and PLD2 in colon, stomach, and liver tissues (Figure 2A).
Positive_regulation (increased) of PLD2 in liver
19) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.34 Pain Relevance 0

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