INT134296

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 14.85
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
hypothalamus 1
colon 1
lung 1
meibomian gland 1
peritoneal macrophages 1
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 416 99.98 Very High Very High Very High
Arthritis 36 99.58 Very High Very High Very High
cytokine 99 98.96 Very High Very High Very High
Central nervous system 9 95.92 Very High Very High Very High
rheumatoid arthritis 40 95.84 Very High Very High Very High
Osteoarthritis 4 94.84 High High
withdrawal 6 94.36 High High
Inflammatory response 15 93.24 High High
Inflammatory stimuli 30 93.00 High High
cINOD 85 92.44 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 20 100.00 Very High Very High Very High
INFLAMMATION 475 99.98 Very High Very High Very High
Cancer 530 99.66 Very High Very High Very High
Disorders Of The Lacrimal System 85 99.58 Very High Very High Very High
Arthritis 36 99.58 Very High Very High Very High
Adenocarcinoma 23 99.52 Very High Very High Very High
Ovarian Cancer 294 99.44 Very High Very High Very High
Malignant Neoplastic Disease 308 98.36 Very High Very High Very High
Disease 89 96.52 Very High Very High Very High
Aging 4 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a more chronic inflammation model, rats with adjuvant-induced arthritis displayed sustained induction of mPGES-1 by immunohistochemistry in the brain vasculature and the paraventricular nucleus of the hypothalamus [20]. mPGES-1 null mice did not generate fevers in response to peripheral LPS injection but did become febrile after intracerebroventricular PGE2 injection [21].
Positive_regulation (induction) of mPGES-1 in hypothalamus associated with inflammation, fever, intracerebroventricular and arthritis
1) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.26 Pain Relevance 0.64
Similar to COX-2, mPGES-1 is highly up-regulated by proinflammatory stimuli and participates in the generation of elevated PGE2 in inflammation.
Positive_regulation (up-regulated) of mPGES-1 associated with inflammation
2) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.07 Pain Relevance 0.84
In mPGES-1 knockout mice injected with LPS, PGE2 synthase activity was only minimally increased in tissues.
Positive_regulation (increased) of mPGES-1 associated with targeted disruption
3) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.14 Pain Relevance 0.25
In the meibomian gland, several genes were upregulated in the female, but not male, including prostaglandin (PG) E synthase 2 (catalyzes the conversion of PG H2 to PG E2 [71]), estrogen related receptor ?
Neg (not) Positive_regulation (upregulated) of E synthase 2 in meibomian gland associated with disorders of the lacrimal system
4) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.54 Pain Relevance 0.07
The increase of COXs, mPGES-1 and EP receptors in epithelial ovarian tumours supports the hypothesis that PGE2 is an important factor for progression (proliferation/angiogenesis) in ovarian tumours.
Positive_regulation (increase) of mPGES-1 associated with ovarian cancer
5) Confidence 0.05 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.54 Pain Relevance 0.08
The role of mPGES-1 for PGE2 production in these cells are essential since isolated peritoneal macrophages from mPGES-1 null mice produced minimal amounts of this prostanoids in response to pro-inflammatory stimuli (LPS) [50].
Positive_regulation (role) of mPGES-1 in peritoneal macrophages associated with inflammatory stimuli
6) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.99 Pain Relevance 0.20
The cell- and stage specific increases of COX-1, COX-2, mPGES-1 and EP1–2, support the hypothesis that PGE2-synthesis and signalling are of importance for malignant transformation and progression in EOC.
Positive_regulation (increases) of mPGES-1 associated with malignant neoplastic disease and ovarian cancer
7) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.59 Pain Relevance 0.03
Increases of COX-1, COX-2, mPGES-1 and EP1 in adenocarcinomas
Positive_regulation (Increases) of mPGES-1 associated with adenocarcinoma
8) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.74 Pain Relevance 0
Significant (p < 0.05) increases of COX-1, COX-2, mPGES-1 and EP1 were demonstrated in the adenocarcinomas (AC) in comparison with normal ovarian tissue, benign adenomas and borderline tumours (B/BL) (Figure 1, 2, 3, 4, 5).
Positive_regulation (increases) of mPGES-1 associated with adenoma, adenocarcinoma, malignant neoplastic disease and cancer
9) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.93 Pain Relevance 0
The increases of COX-1, COX-2, mPGES-1 and EP1–2 in epithelial ovarian cancer, supports the hypothesis that PGE2-synthesis and signalling are of importance for malignant transformation and progression.
Positive_regulation (increases) of mPGES-1 associated with malignant neoplastic disease and ovarian cancer
10) Confidence 0.03 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1657027 Disease Relevance 0.92 Pain Relevance 0.05
IHC revealed staining of the tumour cells, but also increase of COX-1, COX-2, mPGES-1 and EP1–2 in the stromal compartment of AC (grades: moderately-, poorly- and undifferentiated).
Positive_regulation (increase) of mPGES-1 associated with malignant neoplastic disease and cancer
11) Confidence 0.03 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1657027 Disease Relevance 1.00 Pain Relevance 0.04
-stimulated up-regulation of mPGES-1 and COX-2 as well as PGE2 production.


Positive_regulation (up-regulation) of mPGES-1
12) Confidence 0.02 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC2873473 Disease Relevance 0.05 Pain Relevance 0.10
Up to date, three PGE synthases have been described: The microsomal and inducible mPGES-1, the constitutively expressed cytosolic cPGES and the most recently discovered microsomal mPGES-2 [25-29].
Positive_regulation (inducible) of mPGES-1
13) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.64 Pain Relevance 0.20
Increased PGE2 production, via induction of the PGE2-synthesizing enzymes mPGES-1 or COX-2, has also been reported in other cell types stimulated with TNF?
Positive_regulation (induction) of mPGES-1
14) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.29 Pain Relevance 0.11
Microarray and western blot analyses showed that the mRNA and protein expression of the inflammatory induced microsomal prostaglandin E synthase-1 (mPGES-1) was up-regulated by the cytokine TNF?
Positive_regulation (induced) of mPGES-1 associated with inflammation and cytokine
15) Confidence 0.02 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC2873473 Disease Relevance 0.49 Pain Relevance 0.14
-stimulated mPGES-1 and COX-2 expression.
Positive_regulation (stimulated) of mPGES-1
16) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.13 Pain Relevance 0.07
In this work, we therefore aim to explore the signal transduction pathways involved in the regulation of PGE2-regulating enzymes mPGES-1 and COX-2 in TNF?
Positive_regulation (enzymes) of mPGES-1
17) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.47 Pain Relevance 0.26
B signal pathways by SP and Ro abolished the production of PGE2, although the induction of mPGES-1 and COX-2 by TNF?
Spec (investigate) Positive_regulation (induction) of mPGES-1
18) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.06 Pain Relevance 0
However, when considering the similar kinetics of PGE2 production and COX-2 expression, as well as the magnitude of COX-2 induction compared to mPGES-1, COX-2 seems to be the more important enzyme driving the TNF?
Positive_regulation (induction) of mPGES-1
19) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.29 Pain Relevance 0.11
PGH2, which is synthesized by the action of COX-2, is isomerized to PGE2 by terminal prostaglandin E synthase (PGES), and multiple isoforms of terminal PGES have so far been identified.12,16 The cytosolic PGES (cPGES) is constitutively expressed and functionally coupled to COX-1,17 whereas the microsomal prostaglandin E synthase-1 (mPGES-1) is rapidly induced by various stimuli in a COX-2 expression-related manner.12,16 The physiologic relevance of mPGES-1 expression in vivo has been substantiated recently by the finding that mPGES-1-deficient mice display attenuated responses to inflammation and pain.19 Furthermore, mPGES-1 is constitutively expressed in colon, lung, and gastric cancers,20-22 suggesting that it participates in tumorigenesis.
Positive_regulation (induced) of mPGES-1 in lung associated with pain, inflammation and stomach cancer
20) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.48 Pain Relevance 0.14

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