INT134297

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 13.12
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
fibroblasts 10
macrophages 3
central nervous system 2
peritoneal macrophages 2
neutrophils 1
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 136 100.00 Very High Very High Very High
Inflammation 443 99.68 Very High Very High Very High
rheumatoid arthritis 61 99.36 Very High Very High Very High
Central nervous system 20 99.04 Very High Very High Very High
Arthritis 73 96.52 Very High Very High Very High
Osteoarthritis 7 94.84 High High
Inflammatory stimuli 21 93.16 High High
cINOD 57 92.44 High High
withdrawal 14 92.16 High High
Hyperalgesia 6 83.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 509 99.68 Very High Very High Very High
Cancer 166 99.64 Very High Very High Very High
Rheumatoid Arthritis 67 99.36 Very High Very High Very High
Colon Cancer 111 99.04 Very High Very High Very High
Injury 11 98.80 Very High Very High Very High
Targeted Disruption 32 98.56 Very High Very High Very High
Adenoma 15 98.00 Very High Very High Very High
Hypertension 5 97.32 Very High Very High Very High
Arthritis 73 97.04 Very High Very High Very High
Disease 123 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblotting demonstrated increased renal expression of mPGES-1 in DOCA-salt WT mice.
Positive_regulation (increased) of Gene_expression (expression) of mPGES-1
1) Confidence 0.41 Published 2010 Journal Hypertension Section Abstract Doc Link 20065149 Disease Relevance 1.26 Pain Relevance 0.12
Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages.
Positive_regulation (induced) of Gene_expression (expression) of microsomal prostaglandin E synthase-1 in peritoneal macrophages
2) Confidence 0.23 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Title Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.24
Consistent with these findings, increased mPGES-1 expression is seen in synovial tissue of patients with rheumatoid arthritis [14,15].
Positive_regulation (increased) of Gene_expression (expression) of mPGES-1 associated with rheumatoid arthritis
3) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.78 Pain Relevance 0.21
However, further investigations are necessary to more extensively define signaling mechanisms that influence the modulation of induced mPGES-1 expression.
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1
4) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.63 Pain Relevance 0.35
Additionally, peripheral inflammation from carageenan-injected paws was associated with increased mPGES-1 expression and PGE2 levels in the central nervous system [12].
Positive_regulation (increased) of Gene_expression (expression) of mPGES-1 in central nervous system associated with inflammation and central nervous system
5) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.35 Pain Relevance 0.66
Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis.
Positive_regulation (increase) of Gene_expression (expression) of mPGES-1 associated with targeted disruption, inflammation and arthritis
6) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1174970 Disease Relevance 0.29 Pain Relevance 0.19
Further analyses will be required to better define gene regulatory mechanisms that modulate the increased expression of mPGES-1, as seen in inflammation.


Positive_regulation (increased) of Gene_expression (expression) of mPGES-1 associated with inflammation
7) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.42 Pain Relevance 0.19
, up-regulation of mPGES-1 expression is observed in rheumatoid arthritis synovial fibroblasts, as well as in many other cell types [6,23-26].
Positive_regulation (up-regulation) of Gene_expression (expression) of mPGES-1 in fibroblasts associated with rheumatoid arthritis
8) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.05 Pain Relevance 0.82
In some experiments, neutrophils and macrophages were transfected with CR3 siRNA (Invitrogen; Oligo ID MSS205544), PGES-2 siRNA (Ambion; Oligo ID 97139), or respective control siRNA using Lipofectamine 2000+ (Invitrogen) transfecting reagent.
Positive_regulation (transfected) of Gene_expression (transfected) of PGES-2 in macrophages
9) Confidence 0.05 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0 Pain Relevance 0.14
-induced signal transduction leading to increased expression of the PGE2-synthesizing enzymes mPGES-1 and COX-2.
Positive_regulation (increased) of Gene_expression (expression) of mPGES-1
10) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.18 Pain Relevance 0.07
In contrast, these two signal pathways are demonstrated to be involved in cytokine-induced mPGES-1 expression in colonocytes and orbital fibroblasts [19,38,39].
Positive_regulation (-) of Gene_expression (expression) of mPGES-1 in fibroblasts associated with cytokine
11) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.56 Pain Relevance 0.30
Moreover, the induction of mPGES-1 and COX-2 expression, in response to TNF?
Positive_regulation (induction) of Gene_expression (expression) of mPGES-1
12) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.06 Pain Relevance 0.03
In agreement with our previous studies [4,30,31], the protein expression of mPGES-1 and COX-2 was up-regulated by the inflammatory mediator TNF?
Positive_regulation (up-regulated) of Gene_expression (expression) of mPGES-1 associated with inflammation
13) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.36 Pain Relevance 0.18
-induced mPGES-1 and COX-2 expression and PGE2 production, gingival fibroblasts were treated with the specific JNK inhibitor SP600125 (SP) [47].
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 in fibroblasts
14) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
-induced mPGES-1 expression, which in concert with COX-2 regulates PGE2 production in gingival fibroblasts, indicates that this signal pathway may also be of importance in the pathogenesis of periodontitis.
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 in fibroblasts associated with periodontitis
15) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.60 Pain Relevance 0.25
To our knowledge, this is the first study pointing out the involvement of JNK in up-regulation of mPGES-1 expression in TNF?
Positive_regulation (up-regulation) of Gene_expression (expression) of mPGES-1
16) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.10 Pain Relevance 0.10
Induction of mPGES-1 expression using another inflammatory mediator, IL-1?
Positive_regulation (Induction) of Gene_expression (expression) of mPGES-1 associated with inflammation
17) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.53 Pain Relevance 0.22
may not be entirely responsible for the increased expression of mPGES-1 and COX-2.
Positive_regulation (increased) of Gene_expression (expression) of mPGES-1
18) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.09 Pain Relevance 0.05
In contrast, these two signal pathways are demonstrated to be involved in cytokine-induced mPGES-1 expression in colonocytes and orbital fibroblasts [19,38,39].
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 in fibroblasts associated with cytokine
19) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.56 Pain Relevance 0.30
In some experiments, neutrophils and macrophages were transfected with CR3 siRNA (Invitrogen; Oligo ID MSS205544), PGES-2 siRNA (Ambion; Oligo ID 97139), or respective control siRNA using Lipofectamine 2000+ (Invitrogen) transfecting reagent.
Positive_regulation (transfected) of in neutrophils Gene_expression (transfected) of PGES-2 in macrophages
20) Confidence 0.02 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0 Pain Relevance 0.14

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