INT134298

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 96
Total Number 117
Disease Relevance 56.52
Pain Relevance 17.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
fibroblasts 11
chondrocytes 3
stroma 2
macrophages 2
lung 2
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2060 100.00 Very High Very High Very High
Intracerebroventricular 18 100.00 Very High Very High Very High
cytokine 576 99.82 Very High Very High Very High
dexamethasone 21 99.78 Very High Very High Very High
Pain 64 99.66 Very High Very High Very High
COX-2 inhibitor 114 99.40 Very High Very High Very High
rheumatoid arthritis 227 99.36 Very High Very High Very High
Arthritis 189 99.24 Very High Very High Very High
Central nervous system 60 99.04 Very High Very High Very High
Osteoarthritis 34 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2397 100.00 Very High Very High Very High
Cancer 1642 100.00 Very High Very High Very High
Fever 61 100.00 Very High Very High Very High
Colon Cancer 750 99.84 Very High Very High Very High
Ovarian Cancer 420 99.84 Very High Very High Very High
Osteoarthritis 65 99.84 Very High Very High Very High
Targeted Disruption 135 99.70 Very High Very High Very High
Pain 61 99.66 Very High Very High Very High
Hypertension 10 99.44 Very High Very High Very High
Multiple Sclerosis 32 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes formation of PGE(2) from the COX product PGH(2) and has emerged as a therapeutic target.
Gene_expression (product) of mPGES-1
1) Confidence 0.54 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20371706 Disease Relevance 0.28 Pain Relevance 0.19
Immunoblotting demonstrated increased renal expression of mPGES-1 in DOCA-salt WT mice.
Gene_expression (expression) of mPGES-1
2) Confidence 0.46 Published 2010 Journal Hypertension Section Abstract Doc Link 20065149 Disease Relevance 1.25 Pain Relevance 0.12
The present study was undertaken to examine the effect of mPGES-1 deletion on DOCA-salt hypertension.
Gene_expression (deletion) of mPGES-1 associated with hypertension
3) Confidence 0.40 Published 2010 Journal Hypertension Section Abstract Doc Link 20065149 Disease Relevance 0.86 Pain Relevance 0.19
However, LXR ligands did not influence the expression of microsomal PGES-2 (mPGES-2) or cytosolic PGES (cPGES) protein.
Gene_expression (expression) of mPGES-2
4) Confidence 0.30 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.25
These results suggest that LXR ligands diminish PGE(2) production by inhibiting the LPS-induced gene expression of the COX-2-mPGES-1 axis in LPS-activated macrophages.
Gene_expression (expression) of COX-2-mPGES-1 in macrophages
5) Confidence 0.30 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.43 Pain Relevance 0.22
However, LXR ligands did not influence the expression of microsomal PGES-2 (mPGES-2) or cytosolic PGES (cPGES) protein.
Gene_expression (expression) of microsomal PGES-2
6) Confidence 0.26 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.25
Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages.
Gene_expression (expression) of microsomal prostaglandin E synthase-1 in peritoneal macrophages
7) Confidence 0.26 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Title Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.24
Additionally, peripheral inflammation from carageenan-injected paws was associated with increased mPGES-1 expression and PGE2 levels in the central nervous system [12].
Gene_expression (expression) of mPGES-1 in central nervous system associated with inflammation and central nervous system
8) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.35 Pain Relevance 0.65
However, further investigations are necessary to more extensively define signaling mechanisms that influence the modulation of induced mPGES-1 expression.
Gene_expression (expression) of mPGES-1
9) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.62 Pain Relevance 0.35
, up-regulation of mPGES-1 expression is observed in rheumatoid arthritis synovial fibroblasts, as well as in many other cell types [6,23-26].
Gene_expression (expression) of mPGES-1 in fibroblasts associated with rheumatoid arthritis
10) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.05 Pain Relevance 0.81
In studies examining rheumatoid arthritis synovial cells and osteoarthritis chondrocytes, treatment with dexamethasone decreased mPGES-1 mRNA and protein expression mediated by proinflammatory cytokines [23,25,27].
Gene_expression (expression) of mPGES-1 in chondrocytes associated with rheumatoid arthritis, dexamethasone, osteoarthritis and cytokine
11) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.96 Pain Relevance 0.66
mitogen-activated protein kinase signaling pathways in the regulation of mPGES-1 expression in osteoarthritic chondrocytes stimulated with IL-1?
Gene_expression (expression) of mPGES-1 in chondrocytes associated with osteoarthritis
12) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.70 Pain Relevance 0.35
In wild-type rats and mice, constitutive mPGES-1 expression in tissues such as stomach and kidney appear to contribute to small amounts of basal PGE2 production [9,10].
Gene_expression (expression) of mPGES-1 in kidney
13) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.31 Pain Relevance 0.16
Consistent with these findings, increased mPGES-1 expression is seen in synovial tissue of patients with rheumatoid arthritis [14,15].
Gene_expression (expression) of mPGES-1 associated with rheumatoid arthritis
14) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.77 Pain Relevance 0.21
Another isoform, termed microsomal PGES-2 (mPGES-2), is ubiquitously expressed under basal conditions in many tissues and is activated by reducing agents [8].
Gene_expression (expressed) of mPGES-2
15) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.13 Pain Relevance 0.07
In a more chronic inflammation model, rats with adjuvant-induced arthritis displayed sustained induction of mPGES-1 by immunohistochemistry in the brain vasculature and the paraventricular nucleus of the hypothalamus [20]. mPGES-1 null mice did not generate fevers in response to peripheral LPS injection but did become febrile after intracerebroventricular PGE2 injection [21].
Gene_expression (injection) of mPGES-1 in hypothalamus associated with inflammation, fever, intracerebroventricular and arthritis
16) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.38 Pain Relevance 0.89
Moreover, an antisense oligonucleotide blocking mPGES-1 expression inhibits PGE2 production, osteoclastogenesis, and bone resorption in mouse osteoblast coculture stimulated with IL-1?
Gene_expression (expression) of mPGES-1 in osteoblast associated with osteoporosis and hypercalcemia
17) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.07 Pain Relevance 0.82
Another isoform, termed microsomal PGES-2 (mPGES-2), is ubiquitously expressed under basal conditions in many tissues and is activated by reducing agents [8].
Gene_expression (expressed) of microsomal PGES-2
18) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.13 Pain Relevance 0.07
In rat paws of acute (carrageenan-induced) and chronic (adjuvant-induced) arthritis models, significant up-regulation of mPGES-1 RNA and protein expression was observed, compared with other PGE synthases, and was also associated with elevated PGE2 levels [9,12,13].
Gene_expression (expression) of mPGES-1 associated with arthritis
19) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.66 Pain Relevance 0.21
Further analyses will be required to better define gene regulatory mechanisms that modulate the increased expression of mPGES-1, as seen in inflammation.


Gene_expression (expression) of mPGES-1 associated with inflammation
20) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.42 Pain Relevance 0.19

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