INT134299

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 5.93
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
ovary 2
stroma 1
lung 1
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 85 97.96 Very High Very High Very High
rheumatoid arthritis 1 95.44 Very High Very High Very High
Osteoarthritis 1 94.44 High High
cINOD 38 92.04 High High
Inflammatory stimuli 10 87.48 High High
Pain 2 74.04 Quite High
Inflammatory response 5 64.92 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
endometriosis 10 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cyst 55 98.92 Very High Very High Very High
Ovarian Cancer 210 98.68 Very High Very High Very High
Malignant Neoplastic Disease 220 98.40 Very High Very High Very High
INFLAMMATION 102 97.96 Very High Very High Very High
Disease 7 96.12 Very High Very High Very High
Rheumatoid Arthritis 1 95.44 Very High Very High Very High
Cancer 300 95.36 Very High Very High Very High
Osteoarthritis 1 94.44 High High
Cystadenoma 5 93.76 High High
Endometriosis (extended) 15 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of mPGES-1 had little effect on total lung resistance in either naive or ozone-exposed animals.
Localization (Deletion) of mPGES-1 in lung
1) Confidence 0.60 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20371706 Disease Relevance 0.22 Pain Relevance 0.15
Pharmacologically targeting mPGES-1 may not predispose patients at risk to airway dysfunction.
Localization (targeting) of mPGES-1
2) Confidence 0.53 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20371706 Disease Relevance 0.10 Pain Relevance 0.05
The present study demonstrates, for the first time, increased contents and cell-specific localisation of mPGES-1 and the PGE2 receptors EP1–2 in EOC of different grades and stages compared to normal ovaries.
Localization (localisation) of mPGES-1 in ovaries associated with ovarian cancer
3) Confidence 0.05 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.05 Pain Relevance 0.16
The cellular localization of mPGES-1 in the present study, suggested a close connection to the cells expressing EP1–2 receptors, which also support an autocrine/paracrine regulatory pathway.
Localization (localization) of mPGES-1
4) Confidence 0.05 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.16 Pain Relevance 0.20
Cell-specific localisation of COX-1, COX-2, mPGES-1, EP1 and EP2 in benign, borderline and malignant ovarian tumours
Localization (localisation) of mPGES-1 associated with malignant neoplastic disease and ovarian cancer
5) Confidence 0.05 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.91 Pain Relevance 0
Cell-specific localisation of COX-1, COX-2, mPGES-1, EP1 and EP2 in the normal ovary
Localization (localisation) of mPGES-1 in ovary
6) Confidence 0.05 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.02 Pain Relevance 0
Staining for mPGES-1 was predominantly localized to cells in the stroma.
Localization (localized) of mPGES-1 in stroma
7) Confidence 0.04 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.75 Pain Relevance 0
Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases.
Localization (secretion) of Prostaglandin E2
8) Confidence 0.01 Published 2006 Journal Clin. Immunol. Section Title Doc Link 16540375 Disease Relevance 0.74 Pain Relevance 0.33

General Comments

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