INT13430

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Context Info
Confidence 0.33
First Reported 1991
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) mitochondrion (Abat) extracellular region (Sst)
Anatomy Link Frequency
neurons 2
nerve 2
Abat (Rattus norvegicus)
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 19 100.00 Very High Very High Very High
Somatostatin 13 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Opioid 2 97.68 Very High Very High Very High
cerebral cortex 3 96.32 Very High Very High Very High
substance P 3 90.32 High High
antagonist 1 80.56 Quite High
agonist 2 78.24 Quite High
Neurotransmitter 1 64.24 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
gamma-Aminobutyric acid (GABA) stimulates somatostatin release following activation of a GABA uptake carrier located on somatostatin nerve endings of rat cerebral cortex.
GABA Positive_regulation (stimulates) of Localization (release) of somatostatin in nerve associated with gaba, somatostatin and cerebral cortex
1) Confidence 0.33 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1671101 Disease Relevance 0 Pain Relevance 0.78
Somatostatin inhibited [Met]enkephalin and stimulated VIP release; basal and somatostatin-stimulated VIP release were inhibited by [Met]enkephalin and bicuculline and augmented by naloxone and GABA, implying that inhibitory pathways linking somatostatin, opioid, and GABA neurons regulate VIP interneurons, which in turn regulate tachykinin and probably cholinergic motoneurons.
GABA Positive_regulation (augmented) of Localization (release) of somatostatin-stimulated in neurons associated with gaba, narcan, somatostatin, enkephalin and opioid
2) Confidence 0.16 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9815026 Disease Relevance 0 Pain Relevance 1.16

General Comments

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