INT134315

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.35
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
RT1-Hb-ps1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tail-flick 3 98.82 Very High Very High Very High
fluoxetine 1 98.44 Very High Very High Very High
Fibrositis 4 97.68 Very High Very High Very High
depression 47 91.88 High High
antidepressant 16 89.92 High High
sSRI 4 85.72 High High
Pain 12 82.96 Quite High
diabetic neuropathy 4 75.00 Quite High
Pain threshold 1 61.60 Quite High
Locus ceruleus 1 51.04 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 132 98.58 Very High Very High Very High
Fibromyalgia 4 97.68 Very High Very High Very High
Depression 62 96.80 Very High Very High Very High
Pain 14 82.96 Quite High
Nociception 2 79.92 Quite High
Diabetic Neuropathy 4 75.00 Quite High
Neuropathic Pain 1 73.44 Quite High
Death 1 52.64 Quite High
Obesity 19 47.48 Quite Low
Overweight 3 46.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The following parameters were evaluated: motor nerve conduction velocity (MNCV), sensitivity to noxious thermal and mechanical stimuli using the tail-flick (TF) and tail-pressure (TP) tests, and blood glucose (BG) and HbA1c levels.
Gene_expression (levels) of HbA1c in blood associated with tail-flick
1) Confidence 0.35 Published 2006 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 16541192 Disease Relevance 0.50 Pain Relevance 0.26
In a study with sertraline, glycosylated hemoglobin (HbA1c) levels were reduced during treatment, but did not differ between the sertraline and placebo groups,15,16 whereas no significant reduction in HbA1c levels was observed in patients treated with fluoxetine or paroxetine, although their depressive symptoms were significantly improved.17 Similarly, although escitalopram resulted in a significant reduction of depression score, there was only a small and nonsignificant reduction in fasting blood glucose (FBG) levels and HbA1c levels.18 It would thus appear that selective serotonin reuptake inhibitors (SSRIs) do not have any major effect on metabolic control, even when they produce a significant effect on depressive symptoms.
Gene_expression (levels) of HbA1c in blood associated with depression, ssri and fluoxetine
2) Confidence 0.13 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2819761 Disease Relevance 1.59 Pain Relevance 0.69
A high prevalence of fibromyalgia has been reported among 100 patients with DM, both in type 1 and type 2, and a positive correlation between higher levels of HbA1c and more tender points [15].
Gene_expression (levels) of HbA1c associated with diabetes mellitus and fibrositis
3) Confidence 0.03 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2611990 Disease Relevance 1.26 Pain Relevance 0.39

General Comments

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