INT13432

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 5.36
Pain Relevance 8.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klkb1) extracellular space (Klkb1) extracellular region (Klkb1)
Anatomy Link Frequency
plasma 6
neurons 3
Neuronal 1
lumbar region 1
nerve 1
Klkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 1299 100.00 Very High Very High Very High
headache 7 99.88 Very High Very High Very High
lumbar region 1 99.28 Very High Very High Very High
Somatosensory cortex 42 99.10 Very High Very High Very High
sodium channel 65 98.64 Very High Very High Very High
addiction 33 98.54 Very High Very High Very High
Paracetamol 4 98.48 Very High Very High Very High
nav1.8 73 97.82 Very High Very High Very High
intrathecal 7 96.32 Very High Very High Very High
Pain 33 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 6 99.88 Very High Very High Very High
Viral Meningitis 9 99.84 Very High Very High Very High
Acute Liver Failure 8 99.76 Very High Very High Very High
Nervous System Injury 34 99.38 Very High Very High Very High
Overdose 1 95.20 Very High Very High Very High
Obesity 3 94.08 High High
Neuropathic Pain 63 93.64 High High
Demyelinating Disease 26 93.56 High High
INFLAMMATION 20 93.36 High High
Diabetes Mellitus 3 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A counterintuitive and easily testable prediction is that decreasing temperature will increase channel noise effects on APs, e.g., as spontaneously open channels would stay open longer and increase the amount of charge delivered to the membrane [19].
Positive_regulation (increase) of APs associated with action potential
1) Confidence 0.57 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.23
This activation of plasma prekallikrein and kinin-release were inhibited in the presence of SBTI.
Positive_regulation (activation) of plasma prekallikrein in plasma
2) Confidence 0.50 Published 1989 Journal Agents Actions Section Abstract Doc Link 2801319 Disease Relevance 0.17 Pain Relevance 0.34
Axonal memory effects have been previously measured in axons [35], where selective conduction of APs was, for example, dependent on inactivation of a K channel [36].
Positive_regulation (conduction) of APs associated with action potential
3) Confidence 0.47 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.29
We observed jump-like propagation in simulations of both spike trains and single APs.
Positive_regulation (simulations) of APs in spike associated with action potential
4) Confidence 0.41 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.32
m axon to support conduction, at which point the number of channels sustaining an AP is large enough to conduct APs continuously (see Figure S2).


Positive_regulation (conduct) of APs associated with action potential
5) Confidence 0.41 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.29
APs generated by the same stimulus are not precisely aligned across trials, and the misalignment in the AP set grows considerably the further APs propagate.
Positive_regulation (generated) of APs associated with action potential
6) Confidence 0.38 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.34
APs that are triggered across trials by the same stimulus event form an AP set.
Positive_regulation (triggered) of APs associated with action potential
7) Confidence 0.38 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.61
Tuberculoventral-like cells were not spontaneously active, but APs could be elicited by inward current injection.
Positive_regulation (elicited) of APs associated with action potential
8) Confidence 0.27 Published 1997 Journal J Basic Clin Physiol Pharmacol Section Abstract Doc Link 9429984 Disease Relevance 0 Pain Relevance 0.44
Verapamil dramatically increased the duration of APs in fusiform-like cells and had no effect on tuberculoventral-like cells.
Positive_regulation (increased) of APs associated with action potential
9) Confidence 0.27 Published 1997 Journal J Basic Clin Physiol Pharmacol Section Abstract Doc Link 9429984 Disease Relevance 0 Pain Relevance 0.65
However, several changes are apparent: the threshold of activation of the APs is greater in the absence of TJs, the peak amplitude is decreased, and depolarizing afterpotentials are larger.
Positive_regulation (activation) of APs
10) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0
It has been reported that rat nerve injury tended to reduce rheobase and increase the number of APs in response to the same depolarizing currents injection, the AP amplitude and spike width [47-49], many of which mimic those nonsynaptic plasticity found in learning models [40].
Positive_regulation (increase) of APs in nerve associated with nervous system injury
11) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2807858 Disease Relevance 0.54 Pain Relevance 0.36
APs generated from the TJM and the DCM under most conditions used in Fig. 6 (A–C) are shown for 0.6- (Fig. 6 D) and 4.0-?
Positive_regulation (generated) of APs
12) Confidence 0.11 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.03
We hypothesized that i) AP amplitude should decrease as a function of membrane potential, because membrane potential determines the degree of inactivation for the various sodium channel subtypes, and that ii)the presence of Nav1.8 should shift the voltage-dependence of AP amplitude in a depolarized direction, permitting relatively large APs to be generated even in depolarized neurons.


Positive_regulation (generated) of APs in neurons associated with addiction, action potential, sodium channel and nav1.8
13) Confidence 0.09 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0.23 Pain Relevance 1.12
Figure 6A-C show representative recordings of APs elicited in RS, IM, and IB neurons by a 400 ms depolarizing current.
Positive_regulation (elicited) of APs in neurons
14) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2807858 Disease Relevance 0.82 Pain Relevance 0.60
Neuronal communication relies on action potentials (APs) generated by the activity of voltage-gated sodium channels (VGSCs) following membrane depolarisation.
Positive_regulation (generated) of APs in Neuronal associated with action potential and sodium channel
15) Confidence 0.08 Published 2010 Journal The Journal of Physiology Section Body Doc Link PMC2887988 Disease Relevance 0.13 Pain Relevance 0.69
L3 in vS1, did not cause APs in the target location (Figure S2), indicating that synaptic activity did not cause APs in neurons that were not directly photostimulated.
Neg (not) Positive_regulation (cause) of APs in neurons associated with somatosensory cortex and action potential
16) Confidence 0.05 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.40
RESULTS: HFD-fed mice developed obesity, increased plasma FFA and insulin concentrations, and impaired glucose tolerance.
Positive_regulation (increased) of plasma FFA in plasma
17) Confidence 0.04 Published 2007 Journal Diabetes Section Body Doc Link 17626889 Disease Relevance 0.19 Pain Relevance 0
Are these low iP rates in agreement with the iP rates observed in the whole recording, or do iPs dominantly occur at a greater temporal distance to the APs?
Positive_regulation (distance) of APs associated with action potential
18) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749334 Disease Relevance 0 Pain Relevance 0.09
Acetaminophen-treated mice consistently displayed signs characteristic of FHF, including elevated plasma aminotransferase activity.
Positive_regulation (elevated) of plasma aminotransferase in plasma associated with paracetamol and acute liver failure
19) Confidence 0.01 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.79 Pain Relevance 0.37
The frequent elevation of Prostatic-Specific Antigen (PSA) serum level vanish, moreover, its role of a differential factor.
Positive_regulation (elevation) of Prostatic-Specific Antigen
20) Confidence 0.01 Published 1996 Journal Arch Ital Urol Androl Section Abstract Doc Link 9162375 Disease Relevance 0.67 Pain Relevance 0.30

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