INT134341

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.06
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD55) plasma membrane (CD55)
Anatomy Link Frequency
neck 3
erythrocytes 2
skeletal muscle 1
epithelial cells 1
granulocytes 1
CD55 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 73 99.76 Very High Very High Very High
Inflammatory response 5 91.52 High High
abdominal pain 5 89.92 High High
spinal inflammation 109 87.96 High High
peptic ulcer disease 1 63.32 Quite High
Pain 19 50.00 Quite Low
Migraine 4 50.00 Quite Low
cytokine 6 49.28 Quite Low
Infliximab 78 46.04 Quite Low
spondylitis 12 31.04 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 73 99.76 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 173 99.66 Very High Very High Very High
Lifespan 2 99.64 Very High Very High Very High
Hemolysis 58 99.52 Very High Very High Very High
Muscular Dystrophy 12 99.24 Very High Very High Very High
Communicable Diseases 1 98.16 Very High Very High Very High
Anaemia 21 97.32 Very High Very High Very High
Thrombosis 39 96.16 Very High Very High Very High
Disease 108 96.12 Very High Very High Very High
Sprains And Strains 2 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The relative risk for a 1-year disability increased by 3.5 with initial intense neck pain and headaches, by 4.6 times with reduced CROM and by four times with multiple non-painful complaints.
Negative_regulation (reduced) of CROM in neck
1) Confidence 0.58 Published 2008 Journal Eur. J. Neurol. Section Body Doc Link 18803651 Disease Relevance 0.13 Pain Relevance 0
CONCLUSION: Neck pain is significantly associated with reduced CROM as demonstrated by both VR and conventional assessment methods.
Negative_regulation (reduced) of CROM in Neck
2) Confidence 0.54 Published 2010 Journal Spine Section Body Doc Link 20110842 Disease Relevance 0 Pain Relevance 0
Individuals with neck pain usually have reduced CROM.
Negative_regulation (reduced) of CROM in neck
3) Confidence 0.51 Published 2009 Journal Headache Section Body Doc Link 18783446 Disease Relevance 0.09 Pain Relevance 0
A flow cytometry evaluation of CD55 and/or CD59, CD59, and CD48 expression in erythrocytes, granulocytes, and monocytes, respectively, showed that the respective proportions of negative populations were 5.6%, 97.1%, and 96.2%.
Negative_regulation (evaluation) of CD55 in monocytes
4) Confidence 0.39 Published 2007 Journal Int. J. Hematol. Section Abstract Doc Link 17988986 Disease Relevance 1.70 Pain Relevance 0.09
Thus, in the absence of a very high expression of CRegs on the corneal epithelium, bacterially induced loss of DAF and CD59 could be deleterious to the cornea and lead to vision loss after the putative pathogen has been destroyed by the complement system.
Negative_regulation (loss) of DAF in cornea
5) Confidence 0.31 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.70 Pain Relevance 0.03
Moreover, a down-regulation of the complement inhibitory factor, CD55 in the skeletal muscle of mice and patients with DYSF-deficient muscular dystrophy was recently demonstrated, resulting in an increased susceptibility of DYSF-deficient human myotubes to complement attack in vitro [5].
Negative_regulation (regulation) of CD55 in skeletal muscle associated with muscular dystrophy
6) Confidence 0.28 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 1.11 Pain Relevance 0.22
Indeed, in dysferlinopathies, there is evidence of immune system involvement including the presence of muscle inflammation and a down regulation of the complement inhibitory factor, CD55.


Negative_regulation (regulation) of CD55 in immune system associated with inflammation
7) Confidence 0.28 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2912795 Disease Relevance 0.55 Pain Relevance 0.05
A low level of complement activation is a constant physiological phenomenon greatly amplified during inflammatory or infectious diseases; thus, PNH erythrocytes chronically undergo intravascular hemolysis in PNH patients due to CD55 and CD59 deficiency, with a lifespan reduced to 10% compared with that of normal RBCs (Wiedmer et al 1993).
Negative_regulation (deficiency) of CD55 in RBCs associated with inflammation, lifespan, hemolysis, paroxysmal nocturnal hemoglobinuria and communicable diseases
8) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.24 Pain Relevance 0.05
A flow cytometry evaluation of CD55 and/or CD59, CD59, and CD48 expression in erythrocytes, granulocytes, and monocytes, respectively, showed that the respective proportions of negative populations were 5.6%, 97.1%, and 96.2%.
Negative_regulation (evaluation) of CD55 in erythrocytes
9) Confidence 0.13 Published 2007 Journal Int. J. Hematol. Section Abstract Doc Link 17988986 Disease Relevance 1.70 Pain Relevance 0.09
A flow cytometry evaluation of CD55 and/or CD59, CD59, and CD48 expression in erythrocytes, granulocytes, and monocytes, respectively, showed that the respective proportions of negative populations were 5.6%, 97.1%, and 96.2%.
Negative_regulation (evaluation) of CD55 in granulocytes
10) Confidence 0.13 Published 2007 Journal Int. J. Hematol. Section Abstract Doc Link 17988986 Disease Relevance 1.70 Pain Relevance 0.09
In cultured gastric epithelial cells, H. pylori induced transcriptional up-regulation of DAF, and genetic deficiency of DAF attenuated the development of inflammation among H. pylori-infected mice.
Negative_regulation (deficiency) of DAF in epithelial cells associated with inflammation
11) Confidence 0.12 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16543227 Disease Relevance 0.56 Pain Relevance 0.15
Histological analysis showed that the thickness of the synovial layer tended to decrease, with a significant reduction of CD55+ synoviocytes at week 12.
Negative_regulation (reduction) of CD55
12) Confidence 0.11 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128942 Disease Relevance 0.42 Pain Relevance 0.13
Furthermore, complement inhibitory activity in normal human intraocular fluid was blocked by inhibiting the function of MCP, DAF, and CD59 [27].
Negative_regulation (inhibiting) of DAF
13) Confidence 0.10 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.17 Pain Relevance 0.05

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