INT13435

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 7.19
Pain Relevance 8.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RTCA) RNA binding (RTCA) nucleus (RTCA)
ligase activity (RTCA)
Anatomy Link Frequency
PGE1 2
ECs 2
skin 2
SH-SY5Y 1
plasma 1
RTCA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 13 99.82 Very High Very High Very High
agonist 226 99.74 Very High Very High Very High
opioid receptor 11 99.58 Very High Very High Very High
adenocard 4 99.50 Very High Very High Very High
Morphine 13 99.40 Very High Very High Very High
melanocortin 1 receptor 26 99.16 Very High Very High Very High
noradrenaline 12 99.08 Very High Very High Very High
Enkephalin 9 98.80 Very High Very High Very High
nociceptor 3 98.74 Very High Very High Very High
Potency 4 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 11 99.84 Very High Very High Very High
Neuroblastoma 13 97.52 Very High Very High Very High
Vibrio Infection 2 97.20 Very High Very High Very High
Increased Venous Pressure Under Development 36 96.80 Very High Very High Very High
Hypertension 18 95.64 Very High Very High Very High
Cv General 3 Under Development 3 95.08 Very High Very High Very High
Skin Cancer 13 95.04 Very High Very High Very High
Myocardial Infarction 5 94.76 High High
Bordatella Infection 3 94.08 High High
Endotoxemia 1 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclic GMP is probably a second messenger in vascular nociceptors that are excited by nitric oxide (NO), because NO is known to activate the guanylate cyclase.
Positive_regulation (activate) of cyclase in nociceptors associated with nociceptor
1) Confidence 0.60 Published 1997 Journal Pain Section Abstract Doc Link 9060017 Disease Relevance 0.41 Pain Relevance 0.74
Noradrenaline reactivity, plasma NA, alpha 2-adrenoceptor density, and adenylate cyclase activity were measured before and after a 24-h infusion of NA at a subpressor dose (0.02 micrograms/kg per min, n = 13), and also after application of drugs known to increase (nifedipine and furosemide) or decrease (clonidine) plasma NA.
Positive_regulation (measured) of cyclase in plasma associated with noradrenaline and clonidine
2) Confidence 0.60 Published 1987 Journal J Hypertens Suppl Section Abstract Doc Link 2832574 Disease Relevance 0.16 Pain Relevance 0.59
Meanwhile adenylate cyclase was inhibited and guanylate cyclase was stimulated.
Positive_regulation (stimulated) of cyclase
3) Confidence 0.47 Published 1987 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2826349 Disease Relevance 0 Pain Relevance 0.37
Beta-adrenergic stimulation is known to induce adenylate cyclase activation, which results in cyclic AMP accumulation through stimulatory guanosine 5-triphosphate (GTP) binding proteins in the keratinocytes.
Positive_regulation (activation) of cyclase in keratinocytes
4) Confidence 0.41 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1671406 Disease Relevance 0 Pain Relevance 0.22
D1 sites are coupled to adenylate cyclase as shown by a dose-dependent cAMP accumulation from 10(-8) M to 10(-5) M dopamine concentrations.
Positive_regulation (coupled) of cyclase associated with dopamine
5) Confidence 0.39 Published 1984 Journal Int. J. Cancer Section Abstract Doc Link 6094366 Disease Relevance 0.37 Pain Relevance 0.55
Pretreatment of stably transfected cells with cholera toxin abolished the 5-HT-mediated elevation of [cAMP]i, indicating that the 5-HT7(a) subtype directly interacts with Galphas protein(s) to activate adenylate cyclase(s).
Positive_regulation (activate) of cyclase associated with vibrio infection
6) Confidence 0.23 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808674 Disease Relevance 0.10 Pain Relevance 0.24
However, evidence from in vitro studies suggests that NTG induces activation of guanylate cyclase via a series of enzymatic reactions that are modulated by the availability of sulfhydryl groups.
Positive_regulation (activation) of cyclase
7) Confidence 0.20 Published 1983 Journal Circulation Section Abstract Doc Link 6139183 Disease Relevance 0.15 Pain Relevance 0.06
Chronic exposure of all-trans-retinoic acid-differentiated SH-SY5Y cells to morphine (10 mu M; 2 days) results in sensitization of adenylate cyclase as characterized by a significant increase in both PGE1 receptor-mediated as well as receptor-independent (NaF, 10 mM; forskolin, 100 mu M) stimulation of effector activity.
Positive_regulation (sensitization) of cyclase in SH-SY5Y associated with morphine
8) Confidence 0.18 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919301 Disease Relevance 0.15 Pain Relevance 0.36
In addition, antagonist-induced increases in adenylate cyclase activity were observed only after chronic PLO17 administration.2+ Finally, chronic pretreatment of cells with PLO17 (10 microM) resulted in a significant decrease in mu opioid, but not delta opioid receptor, binding, whereas treatment with DPDPE (0.3 microM) resulted in a significant decrease in delta opioid, but not mu opioid receptor binding.
Positive_regulation (increases) of cyclase associated with antagonist, mu opioid receptor, opioid receptor and opioid
9) Confidence 0.11 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8035314 Disease Relevance 0.15 Pain Relevance 1.05
RECENT FINDINGS: Experimental studies have shown that glyceryl trinitrate (GTN), calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase activating polypeptide-38 (PACAP38) and prostaglandin I2 (PGI2) induce migraine-like attacks in migraine suffers indistinguishable from their spontaneous attacks.
Positive_regulation (activating) of cyclase in pituitary
10) Confidence 0.11 Published 2010 Journal Curr. Opin. Neurol. Section Body Doc Link 20173638 Disease Relevance 0.09 Pain Relevance 0
EDRF is a potent, endogenous vasodilator that is produced and released from endothelial cells and subsequently causes the relaxation of VSM through the activation of soluble guanylate cyclase and an increase in VSM cyclic GMP.
Positive_regulation (activation) of cyclase in endothelial cells
11) Confidence 0.09 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0.05 Pain Relevance 0
The recent realization that EDRF serves as the second messenger for guanylate cyclase activation and cyclic GMP production in a variety of cell types outside of the cardiovascular system, including renal and respiratory epithelium, cerebellar neurons, macrophages, and adrenocytes, suggests even broader implications.
Positive_regulation (activation) of cyclase in epithelium
12) Confidence 0.09 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 1.08 Pain Relevance 0.14
The differentiated cells had a relatively high activity of adenylate cyclase and cyclic AMP phosphodiesterase, and a high intracellular level of cyclic AMP. 3.
Positive_regulation (activity) of cyclase
13) Confidence 0.06 Published 1987 Journal Int. J. Biochem. Section Abstract Doc Link 2830153 Disease Relevance 0.28 Pain Relevance 0.45
RA treatment of SH-SY5Y cells increases both the number of PGE1 binding sites and PGE1-stimulated adenylate cyclase activity, but significantly reduced amounts of Gs alpha were found.
Positive_regulation (increases) of cyclase in PGE1 associated with rheumatoid arthritis
14) Confidence 0.05 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.29 Pain Relevance 0.11
With respect to stimulatory receptor systems, a reciprocal regulation was observed for prostaglandin E1 (PGE1) receptors and Gs alpha, the G protein subunit activating adenylate cyclase.
Positive_regulation (activating) of cyclase in PGE1
15) Confidence 0.05 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.30 Pain Relevance 0.11
Under the same conditions, stimulation of adenylate cyclase by prostaglandin E1 was unchanged.
Positive_regulation (stimulation) of cyclase
16) Confidence 0.04 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6319678 Disease Relevance 0.32 Pain Relevance 0.37
When the truncated mu(C delta 45) receptor was stably expressed in human embryonic kidney (HEK) 293 cells, the efficacy and the potency of [D-Ala2,N-Me-Phe4,Gly-ol5]enkephalin (DAMGO), a specific mu-opioid receptor agonist, to inhibit forskolin-stimulated adenylate cyclase activity were not significantly affected.
Positive_regulation (forskolin-stimulated) of cyclase in HEK associated with agonist, opioid receptor, enkephalin and potency
17) Confidence 0.04 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037504 Disease Relevance 0 Pain Relevance 0.43
The vasodilating effects of NAC may be caused by a direct relaxing action on vascular smooth muscle or by modulation of nitric oxide, which activates guanylate cyclase, leading to an increase in cyclic guanosine monophosphate accumulation and smooth muscle relaxation [4,39].
Positive_regulation (activates) of cyclase in smooth muscle
18) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC420025 Disease Relevance 0.09 Pain Relevance 0.06
The binding of the ligand to the receptor activates adenylate cyclase and a number of phospholipases (A, C, and D) and increases intracellular levels of cAMP and calcium.
Positive_regulation (activates) of cyclase
19) Confidence 0.04 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15228497 Disease Relevance 0.52 Pain Relevance 0
Activation of the prostaglandin E(2) (PGE(2)) EP(4) receptor, a G-protein-coupled receptor (GPCR), results in increases in intracellular cyclic AMP (cAMP) levels via stimulation of adenylate cyclase.
Positive_regulation (stimulation) of cyclase
20) Confidence 0.03 Published 2008 Journal Life Sci. Section Abstract Doc Link 18155068 Disease Relevance 0 Pain Relevance 0.08

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