INT134375

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.40
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cflar)
Anatomy Link Frequency
neuroblasts 1
neuronal precursors 1
proximal 1
NSCs 1
neural 1
Cflar (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 22 99.72 Very High Very High Very High
cytokine 77 99.52 Very High Very High Very High
Hippocampus 10 98.44 Very High Very High Very High
antidepressant 2 95.80 Very High Very High Very High
Serotonin 4 93.60 High High
Central nervous system 3 92.92 High High
Infliximab 52 90.00 High High
chemokine 14 87.36 High High
Inflammation 78 87.20 High High
cINOD 14 85.68 High High
Disease Link Frequency Relevance Heat
Apoptosis 567 100.00 Very High Very High Very High
Toxicity 9 100.00 Very High Very High Very High
Targeted Disruption 29 99.96 Very High Very High Very High
Inflammatory Bowel Disease 82 99.66 Very High Very High Very High
Cancer 169 99.64 Very High Very High Very High
Suicidal Behaviour 163 98.48 Very High Very High Very High
Death 153 98.42 Very High Very High Very High
Disease 127 97.60 Very High Very High Very High
Epstein-barr Virus 17 97.20 Very High Very High Very High
Fever 6 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice that were shown to be heterozygous for the targeted allele were mated to Flip recombinase-expressing transgenic mice to remove the neo cassette.
Gene_expression (expressing) of Flip associated with targeted disruption
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.15 Pain Relevance 0
The up-regulated expression of Bcl-2, Bcl-xL and the cellular FLICE-inhibitory protein (c-FLIP) in fluoxetine-treated NSCs was detected by real-time RT-PCR.
Gene_expression (expression) of cellular FLICE-inhibitory protein in NSCs associated with fluoxetine
2) Confidence 0.19 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16545775 Disease Relevance 0.25 Pain Relevance 0.96
The intrinsic defect in CD occurs in the mitochondrial pathway of apoptosis (imbalance of mitochondrial bcl-2/bax), whereas in UC it results from overexpression of FLICE-inhibitory protein (FLIP) and impairment of the caspase-mediated pathway of apoptosis (Peppelenbosch and van Deventer 2004).
Gene_expression (overexpression) of FLICE-inhibitory protein associated with inflammatory bowel disease, apoptosis and disease
3) Confidence 0.19 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.36 Pain Relevance 0.19
Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell.
Gene_expression (expression) of cellular FLICE-inhibitory protein in hippocampus associated with hippocampus, apoptosis and fluoxetine
4) Confidence 0.15 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 16545775 Disease Relevance 0.26 Pain Relevance 0.99
Our results indicate that embryonic cortical precursors are heterogeneous with respect to cell surface Fas expression and the co-expression of the anti-apoptotic protein FLIP (FLICE/caspase-8 interacting protein).
Gene_expression (expression) of FLIP associated with apoptosis
5) Confidence 0.12 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.41 Pain Relevance 0.07
In addition to survivin, there are several other intracellular proteins that are known to restrain cell death when highly expressed, such as, for example, Bcl-2, Bcl-xL, c-IAP2, XIAP, and FLIP, which also have been found overexpressed in some tumors [61].
Gene_expression (overexpressed) of FLIP associated with cancer and death
6) Confidence 0.10 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.78 Pain Relevance 0.09
We do not as yet know whether FLIP expression defines a phenotypically distinct sub-population of neural precursors.
Spec (whether) Gene_expression (expression) of FLIP in neural
7) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.49 Pain Relevance 0
Overall, our results indicate that cell-surface Fas expression identifies two distinct sub-populations of cortical neuroblasts, the FasHi and FasMod populations, with FLIP co-expressing cells comprising perhaps a third population.
Gene_expression (expressing) of FLIP in neuroblasts
8) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.82 Pain Relevance 0.06
If cyclin-A represents a means for limiting apoptosis, then the induction of cyclin A by sFasL, suggests that neuronal precursors may initiate adaptive anti-apoptotic mechanisms (aside from FLIP expression), in response to the activation of a suicide receptor.


Gene_expression (expression) of FLIP in neuronal precursors associated with suicidal behaviour and apoptosis
9) Confidence 0.08 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.49 Pain Relevance 0
Furthermore, only a small proportion of Fas-expressing cells also express the protein FLIP that is capable of blocking Fas activation [45].
Gene_expression (express) of FLIP
10) Confidence 0.08 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.49 Pain Relevance 0
Competing intrinsic (p53, cell cycle, FLIP expression), proximal (extra-cellular matrix) and extrinsic factors (gonadal hormones) collectively regulate Fas suicide-sensitivity either during neurogenesis, or possibly during neuronal migration, and may ultimately determine which neuroblasts successfully contribute neurons to the differentiating cortical plate.



Gene_expression (expression) of FLIP in proximal associated with suicidal behaviour and neurodegenerative disease
11) Confidence 0.08 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.63 Pain Relevance 0
This was explained by a higher level of cellular FLICE-inhibitory protein (cFLIP) expression that leads to procaspase inactivation.
Gene_expression (expression) of cFLIP
12) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.25 Pain Relevance 0.03
This was explained by a higher level of cellular FLICE-inhibitory protein (cFLIP) expression that leads to procaspase inactivation.
Gene_expression (expression) of FLICE-inhibitory protein
13) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.25 Pain Relevance 0.03
Since this was a retrospective study, the main objectives of the study were the definition of a favorable response rate, 100-day survival and overall survival (OS) of patients treated with a caspofungin-based combination therapy, as well as the safety and toxicity of the combination regimen.
Gene_expression (definition) of safety and toxicity associated with toxicity
14) Confidence 0.03 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1871594 Disease Relevance 1.12 Pain Relevance 0
B modulatory proteins of KSHV, vIL-6, K15, K1, and vFLIP are not encoded by ?
Gene_expression (vFLIP) of vFLIP
15) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.65 Pain Relevance 0.24

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