INT134377

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.18
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 6
DRG 4
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cold hyperalgesia 10 99.82 Very High Very High Very High
dorsal root ganglion 32 99.28 Very High Very High Very High
Eae 14 98.60 Very High Very High Very High
Kinase C 23 96.90 Very High Very High Very High
agonist 135 95.80 Very High Very High Very High
Action potential 66 86.72 High High
intrathecal 2 83.44 Quite High
Neuropathic pain 4 83.00 Quite High
imagery 18 74.88 Quite High
GABAergic 3 53.44 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 10 99.82 Very High Very High Very High
Ganglion Cysts 38 99.28 Very High Very High Very High
Nervous System Injury 4 97.20 Very High Very High Very High
Neuropathic Pain 6 96.16 Very High Very High Very High
Toxicity 57 92.60 High High
Primary Sclerosing Cholangitis 12 85.44 High High
Hypersensitivity 2 84.56 Quite High
Targeted Disruption 2 75.00 Quite High
Nociception 17 50.00 Quite Low
Depression 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we precisely examined the incidence of cold hyperalgesia and the changes of TRPA1 and TRPM8 expression in the L4 and L5 DRG following L5 spinal nerve ligation (SNL), because it is likely that the activation of two distinct populations of TRPA1- and TRPM8-expressing small neurons underlie the sensation of cold.
Regulation (changes) of Gene_expression (expression) of TRPM8 in DRG associated with dorsal root ganglion, hyperalgesia, cold hyperalgesia and eae
1) Confidence 0.59 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.15 Pain Relevance 0.83
In contrast, there was no change in the expression of the TRPM8 mRNA/protein in the L4 DRG throughout the 2-week time course of the experiment.
Neg (no) Regulation (change) of Gene_expression (expression) of TRPM8 in DRG associated with dorsal root ganglion
2) Confidence 0.44 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.32 Pain Relevance 1.09
With a failure rate of 11%, TRPM8-transfected neurons were not significantly different from controls (N?
Neg (not) Regulation (different) of Gene_expression (neurons) of TRPM8-transfected in neurons
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0.23 Pain Relevance 0.10
In summary TRPV1 transfection, in the absence of added ligand, depressed evoked synaptic transmission in autaptic hippocampal neurons whereas TRPM8 transfection had no effect.
Neg (no) Regulation (effect) of Gene_expression (transfection) of TRPM8 in neurons
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0.18 Pain Relevance 0.11
In addition to PKC, we found that the selective CaMKII inhibitor KN62 attenuated adaptation of menthol responses in MS/CI neurons, suggesting that CaMKII may play a role in regulating TRPM8 functions in MS/CI neurons.
Regulation (regulating) of Gene_expression (functions) of TRPM8 in neurons associated with kinase c
5) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.12 Pain Relevance 0.32
It may also be interesting to examine species that experience substantial variations (short- or long-term) in environmental temperature, as there may be corresponding changes in TRPM8 expression and/or function that allow for optimal temperature detection under such circumstances.
Regulation (changes) of Gene_expression (expression) of TRPM8
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2683941 Disease Relevance 0 Pain Relevance 0.04
Despite evidence of expression at presynaptic sites, in addition to somatodendritic sites, TRPM8 expression alone exhibited no effects on synaptic transmission.
Neg (no) Regulation (effects) of Gene_expression (expression) of TRPM8
7) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2780724 Disease Relevance 0.18 Pain Relevance 0.17

General Comments

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