INT134378

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 1.74
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal nerve 1
neurons 1
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 122 100.00 Very High Very High Very High
Eae 7 100.00 Very High Very High Very High
Cold hyperalgesia 5 100.00 Very High Very High Very High
Neuropathic pain 3 99.04 Very High Very High Very High
cannabis 7 98.76 Very High Very High Very High
qutenza 138 97.80 Very High Very High Very High
Pain 38 97.60 Very High Very High Very High
TRP channel 71 95.88 Very High Very High Very High
antagonist 10 92.48 High High
Potency 9 92.28 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
Targeted Disruption 5 99.52 Very High Very High Very High
Neuropathic Pain 8 99.04 Very High Very High Very High
Pain 36 97.60 Very High Very High Very High
Hypersensitivity 9 97.48 Very High Very High Very High
Cancer 2 97.24 Very High Very High Very High
Nervous System Injury 3 91.52 High High
INFLAMMATION 23 89.60 High High
Ganglion Cysts 41 87.24 High High
Injury 1 23.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that ethanol inhibits TRPM8 by weakening the PIP(2)-TRPM8 channel interaction; a similar mechanism may contribute to the ethanol-mediated modulation of some other PIP(2)-sensitive TRP channels.
TRPM8 Binding (interaction) of associated with trp channel
1) Confidence 0.48 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17074062 Disease Relevance 0 Pain Relevance 0.10
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.
TRPM8 Binding (ligation) of in spinal nerve associated with targeted disruption, hyperalgesia, cold hyperalgesia and eae
2) Confidence 0.46 Published 2006 Journal Exp. Neurol. Section Title Doc Link 16546170 Disease Relevance 1.21 Pain Relevance 0.83
Our findings suggest that phytocannabinoids and cannabis extracts exert some of their pharmacological actions also by interacting with TRPA1 and TRPM8 channels, with potential implications for the treatment of pain and cancer.
TRPM8 Binding (interacting) of associated with pain, cannabis and cancer
3) Confidence 0.45 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18354058 Disease Relevance 0.19 Pain Relevance 0.30
Ethanol has opposite effects on two members of the transient receptor potential (TRP) family of ion channels: it inhibits the cold-menthol receptor TRPM8, whereas it potentiates the activity of the heat- and capsaicin-gated vanilloid receptor TRPV1.
TRPM8 Binding (inhibits) of associated with qutenza
4) Confidence 0.37 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17074062 Disease Relevance 0 Pain Relevance 0.10
As seen with TRPV1-transfected neurons, these menthol-induced currents in TRPM8-transfected neurons were similar to or larger than currents induced by 30 mM KCl (?
TRPM8-transfected Binding (seen) of in neurons
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0 Pain Relevance 0.20
For the purposes of this study, we therefore focused our attention on xlTRPM8.
xlTRPM8 Binding (attention) of
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2683941 Disease Relevance 0 Pain Relevance 0.05
However, it should be noted that this single residue in TRPM8 does not appear to be involved in the menthol- and cold-sensitivity of the channel, thus suggesting that the TRPM8 can be gated by distinct mechanisms.
TRPM8 Binding (gated) of
7) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0.22
This would not be consistent with the interaction of thermal and agonist stimuli at of closely related channels such as TRPV1 and TRPM8, but the possibility must be considered when trying to untangle the various data regarding TRPA1's postulated role in cold transduction.
TRPM8 Binding (interaction) of associated with agonist
8) Confidence 0.25 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.33 Pain Relevance 0.57
We have shown that citral acts as a partial agonist of TRPV1, TRPV3, TRPM8, and TRPA1.
TRPM8 Spec (partial) Binding (agonist) of associated with agonist
9) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.53
It is unclear whether these compounds use the same binding site as menthol on the TRPM8 protein, or whether they bind to the channel at all.


TRPM8 protein Spec (whether) Binding (bind) of
10) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0 Pain Relevance 0.04

General Comments

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