INT134380

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.78
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 4
DRG 2
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 8 99.28 Very High Very High Very High
Inflammation 5 99.04 Very High Very High Very High
agonist 88 98.96 Very High Very High Very High
bradykinin 2 98.24 Very High Very High Very High
Action potential 44 97.96 Very High Very High Very High
intrathecal 1 96.56 Very High Very High Very High
Inflammatory mediators 2 95.60 Very High Very High Very High
qutenza 74 93.12 High High
Cold hyperalgesia 5 91.24 High High
Eae 7 88.48 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 99.28 Very High Very High Very High
INFLAMMATION 5 99.04 Very High Very High Very High
Hyperalgesia 5 91.24 High High
Nervous System Injury 2 90.20 High High
Targeted Disruption 1 75.00 Quite High
Neuropathic Pain 3 62.56 Quite High
Hypersensitivity 1 50.96 Quite High
Toxicity 38 5.00 Very Low Very Low Very Low
Depression 8 5.00 Very Low Very Low Very Low
Primary Sclerosing Cholangitis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a high degree of functional co-expression of TRPM8, the receptors for the inflammatory agents bradykinin, prostaglandin E2 and histamine, and TRPA1 in cultured sensory neurones.
Negative_regulation (degree) of Gene_expression (co-expression) of TRPM8 associated with inflammation and bradykinin
1) Confidence 0.43 Published 2007 Journal Exp Brain Res Section Abstract Doc Link 17006682 Disease Relevance 0.58 Pain Relevance 0.38
In the injured L5 DRG, on the other hand, both TRPA1 and TRPM8 expression decreased over 2 weeks after ligation.
Negative_regulation (decreased) of Gene_expression (expression) of TRPM8 in DRG associated with dorsal root ganglion
2) Confidence 0.42 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.20 Pain Relevance 1.02
When we applied these exogenous compounds while recording from TRPM8-transfected neurons in current-clamp, we again observed bursts of 1–6 action potentials and a steady state membrane potential of ?
Negative_regulation (recording) of Gene_expression (neurons) of TRPM8-transfected in neurons associated with action potential
3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0 Pain Relevance 0.25
Compared to brief (0–30 min) application of agonist, normalized current amplitudes for both TRPV1- and TRPM8-transfected neurons were significantly decreased after 4 hr application of their respective agonists (Figure 4C and 4D).
Negative_regulation (decreased) of Gene_expression (neurons) of TRPM8-transfected in neurons associated with agonist
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0 Pain Relevance 0.58

General Comments

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