INT134381

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 8.31
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 8
sensory neurons 3
DRG 3
bladder 1
afferent neurons 1
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 56 100.00 Very High Very High Very High
Root ganglion neuron 37 100.00 Very High Very High Very High
Opioid 90 99.98 Very High Very High Very High
member 8 6 99.96 Very High Very High Very High
Kinase C 301 99.92 Very High Very High Very High
Cold hyperalgesia 5 99.82 Very High Very High Very High
Pain 33 99.80 Very High Very High Very High
agonist 174 99.56 Very High Very High Very High
dorsal root ganglion 296 99.28 Very High Very High Very High
Dorsal horn neuron 30 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 429 100.00 Very High Very High Very High
Hyperalgesia 5 99.82 Very High Very High Very High
Pain 41 99.80 Very High Very High Very High
Neuropathic Pain 10 99.56 Very High Very High Very High
Nociception 242 98.80 Very High Very High Very High
Overactive Bladder 5 97.88 Very High Very High Very High
Bladder Disease 3 96.56 Very High Very High Very High
INFLAMMATION 22 94.72 High High
Increased Venous Pressure Under Development 2 90.92 High High
Nervous System Injury 2 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A role for the PLC/PIP2 (Phospholipase C/phosphatidylinositol (4,5) bisphosphate) second messenger pathway in regulating TRPM8 functions has been well established [16,17,19].
Regulation (regulating) of TRPM8
1) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.54 Pain Relevance 0.30
TRPM8 can be regulated through second messenger systems [16-18].
Regulation (regulated) of TRPM8
2) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.62 Pain Relevance 0.28
It was initially thought that this property of MS/CS neurons might be a result of post-transcriptional regulation of TRPM8 function by protein kinases.
Regulation (regulation) of TRPM8 in neurons
3) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.05 Pain Relevance 0.19
However, our result does not exclude the possibility that TRPM8 activity could be regulated indirectly through PKA pathway [22].
Regulation (regulated) of TRPM8
4) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.36 Pain Relevance 0.04
The effect of these two inhibitors is consistent with a previous study that first suggested the involvement of PKC in regulating TRPM8 function in sensory neurons [18].
Regulation (regulating) of TRPM8 in sensory neurons associated with kinase c
5) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.28 Pain Relevance 0.47
In the present study, we precisely examined the incidence of cold hyperalgesia and the changes of TRPA1 and TRPM8 expression in the L4 and L5 DRG following L5 spinal nerve ligation (SNL), because it is likely that the activation of two distinct populations of TRPA1- and TRPM8-expressing small neurons underlie the sensation of cold.
Regulation (changes) of TRPM8 in DRG associated with dorsal root ganglion, hyperalgesia, cold hyperalgesia and eae
6) Confidence 0.44 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.15 Pain Relevance 0.82
The effects of icilin, a TRPM8 and TRPA1 agonist, on intracellular Ca(2+) ([Ca(2+)](i)) responses of small diameter adult dorsal root ganglia (DRG) neurones were determined.
Spec (determined) Regulation (effects) of TRPM8 in DRG associated with agonist
7) Confidence 0.43 Published 2008 Journal Brain Res. Section Abstract Doc Link 18479674 Disease Relevance 0.34 Pain Relevance 0.42
One possible factor is PIP2, because PIP2 plays an important role in regulating TRPM8 functions and PIP2 hydrolysis accounts for menthol-induced desensitization [16,17].
Regulation (regulating) of TRPM8
8) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.08 Pain Relevance 0.06
We explored two candidate heterologous ligand-gated channels: transient receptor potential vanilloid receptor 1 (TRPV1) and transient receptor potential cation channel, subfamily M, member 8 (TRPM8), which normally are responsible for pain and temperature signal transduction in sensory neurons and respond to the pharmacological ligands capsaicin and menthol, respectively [27], [28], [29].
Regulation (responsible) of TRPM8 in sensory neurons associated with pain, qutenza and member 8
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0.10 Pain Relevance 0.56
This approach has been used previously to differentiate TRPV1, TRPM8 and TRPA1 sensitive inputs to dorsal horn neurons in intact spinal cord slices [25-32].
Regulation (differentiate) of TRPM8 in neurons associated with dorsal horn neuron and spinal cord
10) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987996 Disease Relevance 0.17 Pain Relevance 0.65
Here we have characterized the pharmacological effects of citral on several TRP channels known to be present in dorsal root ganglion neurons, including TRPV1–4, TRPM8, and TRPA1.
Regulation (effects) of TRPM8 in neurons associated with ganglion cysts, trp channel and root ganglion neuron
11) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.33 Pain Relevance 0.29
Targeting TRPM8 channel may provide a new therapeutic opportunity for overactive bladder and painful bladder syndrome.
Regulation (Targeting) of TRPM8 in bladder associated with pain, overactive bladder and bladder disease
12) Confidence 0.27 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18562636 Disease Relevance 0.68 Pain Relevance 0.21
If so, then alteration of TRPM8 thermal activation properties throughout metazoan evolution could tune cold-sensitive neurons to temperatures most relevant to an animal's ecological niche.
Regulation (alteration) of TRPM8 in neurons
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2683941 Disease Relevance 0 Pain Relevance 0.13
The effects of this phospholipid on TRPM8 and TRPV1 are also functionally opposite: PIP(2) is necessary for the activation of TRPM8 but it constitutively inhibits TRPV1.
Regulation (effects) of TRPM8
14) Confidence 0.27 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17074062 Disease Relevance 0 Pain Relevance 0.09
TRPM8 immunoreactivity was found to be present in 7.2% of VG neurons (75/1041 cells, Figure 2a).
Regulation (immunoreactivity) of TRPM8 in neurons associated with ganglion cysts
15) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 0.65 Pain Relevance 0.07
The purpose of this paper is to further uncover the antipyretic mechanisms of 1 by investigating its effects on the mRNA expression levels and functions of both TRPV1 and TRPM8.
Spec (investigating) Regulation (effects) of TRPM8
16) Confidence 0.25 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20390747 Disease Relevance 0.26 Pain Relevance 0
Baseline mPSC frequency, which presumably arose from mEPSCs and mIPSCs from both transfected and non-transfected presynaptic terminals, was highly variable in postsynaptic targets of both TRPM8-transfected (0.1–119.8 Hz) and control (0.4–108.0 Hz) neurons.
Regulation (targets) of TRPM8-transfected in neurons
17) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0 Pain Relevance 0.16
TRPM8-immunoreactivity was detected in a small proportion of the WGA-HRP-labeled bladder afferent neurons in the dorsal root ganglia of the Th13-L1 (1.14%) and the L6-S1 (1.27%), and these neurons were small in size (<600 microm(2)).
Regulation (immunoreactivity) of TRPM8 in dorsal root ganglia
18) Confidence 0.25 Published 2009 Journal Neurosci. Res. Section Abstract Doc Link 19622375 Disease Relevance 0.14 Pain Relevance 0.09
Other second message pathways such as PKA have also been suggested to play roles in regulating TRPM8 functions [22,23].
Regulation (regulating) of TRPM8
19) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.28 Pain Relevance 0.22
These previous studies on the regulation of TRPM8 functions were performed either using heterologous expression system or functionally unidentified sensory neurons.
Regulation (regulation) of TRPM8 in sensory neurons
20) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.27 Pain Relevance 0.27

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