INT134382

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.48
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 2
DRG 2
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 6 99.96 Very High Very High Very High
Neuropathic pain 21 99.38 Very High Very High Very High
Cold hyperalgesia 5 97.20 Very High Very High Very High
Eae 28 96.36 Very High Very High Very High
pregabalin 6 91.56 High High
Inflammatory mediators 2 73.32 Quite High
intrathecal 3 71.60 Quite High
agonist 4 70.36 Quite High
bradykinin 2 68.12 Quite High
Pain 9 57.76 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.96 Very High Very High Very High
Neuropathic Pain 28 99.38 Very High Very High Very High
Hyperalgesia 6 97.20 Very High Very High Very High
Hypersensitivity 35 93.60 High High
Nervous System Injury 5 86.24 High High
Inflammatory Pain 11 82.12 Quite High
Targeted Disruption 5 75.00 Quite High
INFLAMMATION 17 72.92 Quite High
Pain 11 57.76 Quite High
Nociception 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPA1 has been previously implicated in neuropathic pain based on the observation that TRPA1 mRNA expression was found to be increased in uninjured small diameter TrkA+ neurons in the L4 DRG following L5 SNL, and the time course of this upregulation was correlated with the development of cold hypersensitivity [23].
Positive_regulation (increased) of Transcription (expression) of TRPA1 in neurons associated with hypersensitivity and neuropathic pain
1) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 1.14 Pain Relevance 0.68
In the nearby uninjured L4 DRG, TRPA1 mRNA expression increased in trkA-expressing small-to-medium diameter neurons from the 1st to 14th day after the L5 SNL.
Positive_regulation (increased) of Transcription (expression) of TRPA1 in DRG associated with dorsal root ganglion and eae
2) Confidence 0.46 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.34 Pain Relevance 1.02

General Comments

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