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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.13
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PRKG1, MAPK8) cytosol (PRKG1, MAPK8) nucleoplasm (MAPK8)
mitochondrion (MAPK8) response to stress (MAPK8) signal transduction (PRKG1)
Anatomy Link Frequency
colon 3
PRKG1 (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 75.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5 99.48 Very High Very High Very High
Colon Cancer 6 98.96 Very High Very High Very High
Cancer 3 76.00 Quite High
INFLAMMATION 2 74.84 Quite High
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacologic activation of PKG with YC-1 increases JNK phosphorylation and induces apoptosis in colon cancer cells without modulating ERK1/2 phosphorylation or beta-catenin protein expression.
Positive_regulation (activation) of PKG in colon Positive_regulation (increases) of Phosphorylation (phosphorylation) of JNK in colon associated with colon cancer and apoptosis
1) Confidence 0.30 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.13 Pain Relevance 0.14

General Comments

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