INT134405

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PTGS1, HPGDS) nucleus (PTGS1, HPGDS) isomerase activity (HPGDS)
nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Anatomy Link Frequency
megakaryocytes 1
PTGS1 (Homo sapiens)
HPGDS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 85.84 High High
cINOD 1 66.40 Quite High
Disease Link Frequency Relevance Heat
Mastocytoma 1 97.12 Very High Very High Very High
Body Weight 1 96.88 Very High Very High Very High
INFLAMMATION 3 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HQL-79 selectively inhibited PGD2 production by H-PGDS-expressing human megakaryocytes and rat mastocytoma cells with an IC50 value of about 100 microm but only marginally affected the production of other prostanoids, suggesting the tight functional engagement between H-PGDS and cyclooxygenase.
cyclooxygenase Binding (engagement) of H-PGDS in megakaryocytes associated with mastocytoma
1) Confidence 0.01 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16547010 Disease Relevance 0.33 Pain Relevance 0.14

General Comments

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