INT134412

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.70
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (HPGDS) signal transduction (HPGDS) nucleolus (HPGDS)
nucleus (HPGDS) cytoplasm (HPGDS)
Anatomy Link Frequency
megakaryocytes 1
HPGDS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 84.32 Quite High
Bile 3 82.28 Quite High
cINOD 6 73.44 Quite High
Paracetamol 6 65.12 Quite High
aspirin 3 60.20 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
tricyclic antidepressant 3 5.00 Very Low Very Low Very Low
dorsal root ganglion 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 97.52 Very High Very High Very High
Mastocytoma 1 97.12 Very High Very High Very High
Testicular Cancer 11 96.24 Very High Very High Very High
Body Weight 1 95.36 Very High Very High Very High
Hearing Impairment 15 84.56 Quite High
INFLAMMATION 24 84.32 Quite High
Tinnitus 12 80.08 Quite High
Dysesthesia 13 75.44 Quite High
Hypersensitivity 12 72.32 Quite High
Disease 34 70.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H-PGDS bound to the resin was eluted with 50?
PGDS Binding (bound) of
1) Confidence 0.42 Published 2010 Journal Acta Crystallographica Section F: Structural Biology and Crystallization Communications Section Body Doc Link PMC2898477 Disease Relevance 0 Pain Relevance 0
H-PGDS bound to the resin was eluted with 50?
PGDS Binding (eluted) of
2) Confidence 0.32 Published 2010 Journal Acta Crystallographica Section F: Structural Biology and Crystallization Communications Section Body Doc Link PMC2898477 Disease Relevance 0 Pain Relevance 0
reported that crystals of H-PGDS in complexes with novel inhibitors, which were grown in microgravity in 2007, diffracted up to a 1.1?
H-PGDS Binding (complexes) of
3) Confidence 0.31 Published 2011 Journal Journal of Synchrotron Radiation Section Body Doc Link PMC3004263 Disease Relevance 0.51 Pain Relevance 0.19
This dataset contains only the structures of PGDS and mPGES-2 that are known to bind to PGH2.
PGDS Binding (bind) of
4) Confidence 0.27 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
This article presents a review of the human glutathione transferases (GSTs) and their genes, in the context of pharmacogenetics and pharmacogenomics.
GSTs Binding (review) of
5) Confidence 0.24 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.14 Pain Relevance 0
Some ambiguity persists in the enumeration of human GSTs.
GSTs Binding (enumeration) of
6) Confidence 0.21 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0 Pain Relevance 0
Mammalian GSTs of the Alpha, Mu, and Pi classes bind with high affinity to matrices such as S-hexylglutathione-sepharose or S-hexylglutathione-agarose [41, 42], but GST enzymes from other classes, such as Theta, bind poorly or not at all [43].
GSTs Binding (bind) of
7) Confidence 0.20 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.06 Pain Relevance 0.11
HQL-79 selectively inhibited PGD2 production by H-PGDS-expressing human megakaryocytes and rat mastocytoma cells with an IC50 value of about 100 microm but only marginally affected the production of other prostanoids, suggesting the tight functional engagement between H-PGDS and cyclooxygenase.
H-PGDS Binding (engagement) of in megakaryocytes associated with mastocytoma
8) Confidence 0.14 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16547010 Disease Relevance 0.33 Pain Relevance 0.13
Genotyping of these GSTs might be a welcomed step towards a more individualized treatment of patients with metastatic testicular cancer.



GSTs Binding (Genotyping) of associated with testicular cancer
9) Confidence 0.04 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2245909 Disease Relevance 0.67 Pain Relevance 0

General Comments

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