INT134442

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.60
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
retinas 2
liver 1
brain 1
apoptotic cells 1
hippocampus 1
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 2 99.92 Very High Very High Very High
agonist 2 99.72 Very High Very High Very High
Hippocampus 9 99.02 Very High Very High Very High
antagonist 1 98.68 Very High Very High Very High
Inflammation 29 97.76 Very High Very High Very High
ischemia 200 90.88 High High
chemokine 4 89.12 High High
isoflurane 13 83.64 Quite High
anesthesia 24 83.00 Quite High
Pain 1 76.60 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 386 100.00 Very High Very High Very High
Obstructive Jaundice 48 99.16 Very High Very High Very High
INFLAMMATION 34 97.76 Very High Very High Very High
Pancreatitis 52 95.64 Very High Very High Very High
Stress 75 92.76 High High
Injury 31 92.04 High High
Retina Disease 102 91.52 High High
Glioblastoma 5 91.44 High High
Fistula 42 89.84 High High
Cv General 4 Under Development 24 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 1 h after CPB, in 6 rats per group, hippocampus was processed for the apoptotic gene (bcl-2 and bax) messenger RNAs detection by reverse transcriptase polymerase chain reaction, and messenger RNA expression was determined by the ratio of the polymerase chain reaction product of bcl-2 or bax to the beta-actin gene.
Transcription (detection) of bax in hippocampus associated with hippocampus and apoptosis
1) Confidence 0.67 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.41 Pain Relevance 0.25
The therapeutic effects of Salvia miltiorrhizae on OJ rats were more prominent: the expression level of Bax protein (on 21?
Transcription (level) of Bax protein associated with obstructive jaundice
2) Confidence 0.62 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.37 Pain Relevance 0
As for mRNA, the Bax:Bcl-2 and Bax:Bcl-xL protein ratios did not reveal any modulation (1.144±0.238 and 0.970±0.129, respectively; Figure 2E-F).


Transcription (ratios) of Bax
3) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0.06
As for mRNA, the Bax:Bcl-2 and Bax:Bcl-xL protein ratios did not reveal any modulation (1.144±0.238 and 0.970±0.129, respectively; Figure 2E-F).


Transcription (ratios) of Bax
4) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0.06
As for mRNA, the Bax:Bcl-2 and Bax:Bcl-xL protein ratios did not reveal any modulation (1.144±0.238 and 0.970±0.129, respectively; Figure 2E-F).


Neg (not) Transcription (reveal) of Bax
5) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0.06
Although slight differences between mRNA and protein regulation were obtained in ischemic and control retinas, Bax:Bcl-2 and Bax:Bcl-xL ratios were similarly modulated over time.
Transcription (modulated) of Bax in retinas
6) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.61 Pain Relevance 0.26
Although slight differences between mRNA and protein regulation were obtained in ischemic and control retinas, Bax:Bcl-2 and Bax:Bcl-xL ratios were similarly modulated over time.
Transcription (modulated) of Bax in retinas
7) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.61 Pain Relevance 0.26
The strong decline of Bcl-xL was further amplified in the Bax:Bcl-xL ratio (1.446±0.106; p<0.005; Figure 3F) Bcl-2 was not significantly modulated (0.759±0.116), nor was the Bax:Bcl-2 ratio (1.194±0.132, Figure 3C,E).


Neg (not) Transcription (modulated) of Bax
8) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.07 Pain Relevance 0
The effects of antagonist of alpha2-adrenoceptors yohimbine and their agonist clonidine on Bax and Bcl-XL mRNA levels in neonatal rat brain were studied.
Transcription (levels) of Bax in brain associated with antagonist, agonist and clonidine
9) Confidence 0.52 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.42
Expressions of Bax and Bcl-2 at mRNA and protein levels were altered resulting in an increase in Bax : Bcl-2 ratio in apoptotic cells, which also exhibited overexpression of 80 kDa calpain and an increase in calpain-cleaved 145 kDa alpha-spectrin breakdown product.
Transcription (mRNA) of Bax in apoptotic cells associated with apoptosis
10) Confidence 0.49 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17570061 Disease Relevance 1.58 Pain Relevance 0.20
To further investigate whether arsenic exposure affects the expression of Bcl-2 and Bax at the mRNA levels, transcription levels of Bcl-2 and Bax were checked in the liver tissue of the experimental rats.
Transcription (transcription) of Bax in liver
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.72 Pain Relevance 0
There was an increase in caspase-3 and Bax mRNA levels at 4 weeks.
Transcription (levels) of Bax
12) Confidence 0.30 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.70 Pain Relevance 0.06
There was an increase in caspase-3 and Bax mRNA levels at 4W.
Transcription (levels) of Bax
13) Confidence 0.13 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.18 Pain Relevance 0
This inhibition of apoptosis was associated with a decreased mRNA expression of the pro-apoptotic Bax in the presence of EPO (control: 0.65 + 0.09, EPO: 0.18 + 0.01, n = 4, P = 0.02).
Transcription (expression) of Bax associated with apoptosis
14) Confidence 0.12 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954875 Disease Relevance 0.68 Pain Relevance 0.11
Similary EPO (200 U/l) decreased apoptosis in serum starved eEPC by 10 + 4% (n = 4) and decreased mRNA expression of Bax by 15%.


Transcription (expression) of Bax associated with apoptosis
15) Confidence 0.10 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954875 Disease Relevance 0.61 Pain Relevance 0.16

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