INT134443

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.62
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
thymus 3
astrocytes 1
hippocampus 1
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 18 100.00 Very High Very High Very High
Central nervous system 23 90.96 High High
ketamine 15 88.80 High High
anesthesia 7 88.00 High High
medulla 19 85.52 High High
antagonist 5 85.40 High High
nMDA receptor 6 83.36 Quite High
Bile 9 83.32 Quite High
epidural 3 81.96 Quite High
ischemia 28 78.28 Quite High
Disease Link Frequency Relevance Heat
Death 75 99.36 Very High Very High Very High
Neurodegenerative Disease 26 99.04 Very High Very High Very High
Dementia 9 98.40 Very High Very High Very High
Apoptosis 273 97.36 Very High Very High Very High
Autoimmune Disease 15 96.36 Very High Very High Very High
Adhesions 4 95.92 Very High Very High Very High
Cognitive Disorder 1 88.44 High High
Vascular Dementia 1 80.36 Quite High
Reperfusion Injury 8 79.04 Quite High
Coronary Artery Disease 6 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rats, moderate hypothermic CPB with hemodilution is associated with CA1 hippocampus bax and bcl-2 gene expression and neuronal apoptosis during the early post-CPB recovery period.
bax Binding (associated) of in hippocampus associated with hippocampus and neurodegenerative disease
1) Confidence 0.47 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.33 Pain Relevance 0.21
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
bax Binding (ratios) of
2) Confidence 0.36 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
bax Binding (ratios) of
3) Confidence 0.36 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
Bax Binding (immunoreactivity) of in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
4) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.67 Pain Relevance 0.14
B, P-selectin, Bax, Bcl-2, and Caspase-3 protein expression of thymus under light microscope,
Bax Binding (thymus) of in thymus
5) Confidence 0.26 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.25 Pain Relevance 0.20
B, P-selectin, Bax, and Bcl-2 in thymus was negative
Bax Binding (negative) of in thymus
6) Confidence 0.26 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.54 Pain Relevance 0.18
B, P-selectin, Bax, Bcl-2, and Caspase-3 protein expression of thymus under light microscope,
Bax Binding (microscope) of in thymus
7) Confidence 0.26 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.31 Pain Relevance 0.20
If Bax homodimers predominate cell death will occur, but when Bcl-2 and Bax heterodimererization prevails cells can survive.
Bax Binding (heterodimererization) of associated with death
8) Confidence 0.22 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.93 Pain Relevance 0.17
FL-Bid has been shown to be sufficient to induce the oligomerization of Bax/Bak, resulting in its integration into the outer mitochondrial membrane triggering cyt-C release [24].
Bax Binding (oligomerization) of
9) Confidence 0.16 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.55 Pain Relevance 0.04
Among the potential downstream regulators, the ratio of Bax and BCL-XL was determined.
Bax Binding (ratio) of
10) Confidence 0.15 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.32 Pain Relevance 0.23

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