INT134444

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.67
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 24 95.84 Very High Very High Very High
Inflammatory response 3 89.60 High High
Hippocampus 12 89.12 High High
Inflammation 18 86.16 High High
medulla 1 71.76 Quite High
isoflurane 2 61.96 Quite High
anesthesia 2 61.32 Quite High
ischemia 18 41.68 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 15 98.96 Very High Very High Very High
Lactic Acidosis 1 97.58 Very High Very High Very High
Hypothermia 138 96.52 Very High Very High Very High
Hemorrhage 46 95.84 Very High Very High Very High
Vascular System Injuries 4 94.48 High High
Neurodegenerative Disease 8 93.08 High High
Cv General 2 Under Development 18 89.76 High High
INFLAMMATION 21 89.24 High High
Postoperative Complications 1 78.04 Quite High
Injury 61 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of bcl-2 Binding (ratios) of
1) Confidence 0.47 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of bcl-2 Binding (ratios) of
2) Confidence 0.47 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
In a small animal model of lethal hemorrhage treated with profound hypothermia, our team has demonstrated decreased lactic acidosis and improved survival along with a significant decrease in apoptotic proteins, preserved phosphorylated Akt levels, and increased prosurvival intermediates such as Bcl-2 and ?
Positive_regulation (increased) of Bcl-2 Binding (intermediates) of associated with hypothermia, lactic acidosis, cva and apoptosis
3) Confidence 0.06 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.95 Pain Relevance 0.24

General Comments

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