INT134445

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.43
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 3 82.84 Quite High
Hippocampus 6 79.60 Quite High
cerebral cortex 2 75.00 Quite High
isoflurane 1 49.12 Quite Low
anesthesia 2 48.48 Quite Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 14 100.00 Very High Very High Very High
Hypoxia 13 99.90 Very High Very High Very High
Myocardial Infarction 51 88.72 High High
Neurodegenerative Disease 4 80.24 Quite High
Teratoma 2 51.40 Quite High
Infarction 9 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Group 1 had increased bcl-2 and bax protein expression in hippocampal CA1 region at 6 h after CPB (bcl-2, 0.18 +/- 0.05 versus 0.09 +/- 0.01; P = 0.02; bax, 0.20 +/- 0.06 versus 0.04 +/- 0.02; P = 0.01; Group 1 versus Group 2, respectively).
Positive_regulation (had) of Positive_regulation (increased) of bcl-2
1) Confidence 0.47 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.28 Pain Relevance 0.21
The observed activation/upregulation of Akt1 [23], Bcl2 and cell survival associated pathways, such as JAK-STAT [24] and NF?
Positive_regulation (activation) of Positive_regulation (upregulation) of Bcl2
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637970 Disease Relevance 0.41 Pain Relevance 0
We propose that during hypoxia the increased ratio of (pro-apoptotic Bad and Bax/anti-apoptotic Bcl-xl and Bcl-2) in all the three compartments, will lead to altered mitochondrial and nuclear membrane permeability as well as caspase-9 activation in the cytosolic compartment.
Positive_regulation (lead) of Positive_regulation (increased) of Bcl-2 associated with hypoxia and apoptosis
3) Confidence 0.03 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.73 Pain Relevance 0.28

General Comments

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