INT134454

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.32
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EGF, EGFR) signal transduction (EGF, EGFR) extracellular region (EGF, EGFR)
plasma membrane (EGF, EGFR) endosome (EGFR) cell morphogenesis (EGFR)
EGF (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 9 97.20 Very High Very High Very High
Cancer pain 1 87.52 High High
local anesthetic 1 54.00 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
Pain score 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 1 99.76 Very High Very High Very High
Cancer 22 96.56 Very High Very High Very High
Tongue Neoplasms 3 78.40 Quite High
Adhesions 1 70.32 Quite High
Solid Tumor 2 70.04 Quite High
Colon Cancer 17 67.32 Quite High
Apoptosis 2 67.04 Quite High
Pancreatic Cancer 6 66.16 Quite High
Non-small-cell Lung Cancer 12 65.36 Quite High
Metastasis 3 58.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that the inhibition of EGF-stimulated EGFR activity is one of the mechanisms of the antiproliferative effect of lidocaine on CAL27 cells.
EGF Positive_regulation (stimulated) of EGFR associated with lidocaine
1) Confidence 0.56 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551906 Disease Relevance 0.35 Pain Relevance 0.88
Activation of EGFR by ligands, such as EGF, leads to receptor dimerization and activation of intrinsic tyrosine kinase (TK) activity.
EGF Positive_regulation (Activation) of EGFR
2) Confidence 0.29 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2699661 Disease Relevance 0.97 Pain Relevance 0
Growth factor dependent MAPK activation was constrained by dynamic measurements of phosphorylated ERK (ERKpp) levels following stimulation of EGFR with 8nM EGF (Fig. 5D).
EGF Positive_regulation (stimulation) of EGFR
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

General Comments

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