INT134460

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Context Info
Confidence 0.04
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.23
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CISD1)
Anatomy Link Frequency
endothelial cell 1
CISD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 40 100.00 Very High Very High Very High
adenocard 26 100.00 Very High Very High Very High
local anesthetic 48 99.56 Very High Very High Very High
lidocaine 16 98.72 Very High Very High Very High
antagonist 8 95.00 High High
Inflammation 4 93.20 High High
potassium channel 5 75.00 Quite High
agonist 4 58.60 Quite High
ischemia 13 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 27 99.82 Very High Very High Very High
INFLAMMATION 4 93.20 High High
Cv Unclassified Under Development 13 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, tetracaine and procaine had no protective effects and inhibited activation of mitoK(ATP) channels.
Positive_regulation (activation) of mitoK
1) Confidence 0.04 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551907 Disease Relevance 0.25 Pain Relevance 0.88
Flavoprotein fluorescence was used to investigate the effects of local anesthetics on diazoxide-induced activation of mitoK(ATP) channels.
Positive_regulation (activation) of mitoK associated with local anesthetic
2) Confidence 0.03 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551907 Disease Relevance 0.36 Pain Relevance 1.29
In conclusion, amide local anesthetics and the amide analog (YWI) attenuate LPS-induced cell injury, in part, through activation of mitoK(ATP) channels.
Positive_regulation (activation) of mitoK associated with injury and local anesthetic
3) Confidence 0.03 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551907 Disease Relevance 0.26 Pain Relevance 1.07
We hypothesized that lidocaine and other amide local anesthetics protect against endothelial cell injury through activation of the mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) channels.
Positive_regulation (activation) of mitoK in endothelial cell associated with adenocard, injury, lidocaine and local anesthetic
4) Confidence 0.03 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551907 Disease Relevance 0.36 Pain Relevance 1.05
Sequence of activation of PKC, p38MAPK and mitoKATP channels (Study 3)
Positive_regulation (activation) of mitoKATP associated with kinase c
5) Confidence 0.01 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.51

General Comments

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