INT134468

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2006
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 27.09
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Cdk5r1) plasma membrane (Cdk5r1) nucleus (Cdk5r1)
embryo development (Cdk5r1) cell cycle (Cdk5r1) kinase activity (Cdk5r1)
Anatomy Link Frequency
neurons 5
neuronal 4
nerves 1
Cdk5r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 238 99.02 Very High Very High Very High
Inflammation 88 98.52 Very High Very High Very High
Eae 18 98.32 Very High Very High Very High
Hippocampus 129 98.12 Very High Very High Very High
Pain 19 95.36 Very High Very High Very High
Peripheral nervous system 5 91.32 High High
Pyramidal cell 56 86.84 High High
depression 126 86.40 High High
Neurotransmitter 24 83.96 Quite High
anticonvulsant 42 81.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1127 100.00 Very High Very High Very High
Convulsion 955 99.92 Very High Very High Very High
Sclerosis 34 99.72 Very High Very High Very High
Drug Induced Neurotoxicity 29 99.52 Very High Very High Very High
Status Epilepticus 98 99.42 Very High Very High Very High
Inflammatory Bowel Disease 2 99.28 Very High Very High Very High
Death 190 99.16 Very High Very High Very High
Nociception 33 99.06 Very High Very High Very High
Disease 425 98.50 Very High Very High Very High
INFLAMMATION 109 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered nociceptive responses to basal thermal noxious stimuli in p35 knockout (p35(-/-)) and p35-overexpresing transgenic mice (Tgp35) have established the important role of this gene in the nociceptive process.
Gene_expression (overexpresing) of p35 associated with targeted disruption and nociception
1) Confidence 0.48 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.86 Pain Relevance 0.62
Altered nociceptive responses to basal thermal noxious stimuli in p35 knockout (p35(-/-)) and p35-overexpresing transgenic mice (Tgp35) have established the important role of this gene in the nociceptive process.
Gene_expression (overexpresing) of p35 associated with targeted disruption and nociception
2) Confidence 0.48 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.87 Pain Relevance 0.62
Altered nociceptive responses to basal thermal noxious stimuli in p35 knockout (p35(-/-)) and p35-overexpresing transgenic mice (Tgp35) have established the important role of this gene in the nociceptive process.
Gene_expression (overexpresing) of p35 associated with targeted disruption and nociception
3) Confidence 0.48 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.87 Pain Relevance 0.62
CDK-5 along with its activators, p35 and p39, is predominantly expressed in post-mitotic neurons [3].
Gene_expression (expressed) of p35 in neurons
4) Confidence 0.46 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.19 Pain Relevance 0.03
Enhanced CDK-5 activity and expression of p35 are associated with differentiation of cultured neuronal cells as well as accelerated neurite outgrowth [4].
Gene_expression (expression) of p35 in neuronal
5) Confidence 0.46 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.25 Pain Relevance 0.03
Namgung et al [5] reported a high expression of CDK-5 and p35 in regenerating nerves.
Gene_expression (expression) of p35 in nerves
6) Confidence 0.46 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.21 Pain Relevance 0.04
Interestingly, human hippocampal sclerosis is accompanied by p25 generation and altered Cdk5 activity [38].
Gene_expression (generation) of p25 associated with sclerosis
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.44 Pain Relevance 0.11
Furthermore, transient overexpression of Cdk5-activating cofactor, p25, increases NMDAR-mediated plasticity and synaptic transmission [7], [15].
Gene_expression (overexpression) of p25
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.70 Pain Relevance 0.15
Acute seizures in healthy animals and chronic seizures in human epileptics produces elevated levels p25 [54].
Gene_expression (produces) of p25 associated with convulsion
9) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.11 Pain Relevance 0.15
Both conditional KO of Cdk5 [7] and transient overexpression of p25 [5] result in increased synaptic plasticity and learning.
Gene_expression (overexpression) of p25 associated with targeted disruption
10) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.60 Pain Relevance 0.12
During periods of increased Ca2+-influx, neurons produce p25 following calpain activation [58].
Gene_expression (produce) of p25 in neurons
11) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.09 Pain Relevance 0.14
To further assess the role of Cdk5 in acute seizures and the homeostasis of neuronal excitability, status epilepticus was induced pharmacologically in WT mice and p25 levels were assessed in hippocampal lysates.
Gene_expression (levels) of p25 in neuronal associated with convulsion, neuronal excitability and status epilepticus
12) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.51 Pain Relevance 0.09
A dichotomy may also exist for Cdk5/p25?
Gene_expression (exist) of p25
13) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.17 Pain Relevance 0.17
Long-term, but not acute, loss of Cdk5 led to decreased p25 levels, suggesting that Cdk5/p25 may be activated as a homeostatic mechanism to attenuate epileptiform activity.
Gene_expression (levels) of p25
14) Confidence 0.39 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695674 Disease Relevance 0.41 Pain Relevance 0.08
Hence, chemically-induced status epilepticus in normal WT animals caused p25 levels in increase in hippocampal lysates.
Gene_expression (levels) of p25 associated with status epilepticus
15) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.53 Pain Relevance 0.14
A dichotomy may also exist for Cdk5/p25?
Gene_expression (/) of p25
16) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.16 Pain Relevance 0.17
Generation of p25 was also analyzed following electrical electroconvulsive shock.
Spec (analyzed) Gene_expression (Generation) of p25 associated with shock
17) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.40 Pain Relevance 0.15
Cdk5 KO may impair calpain-mediated p25 generation and thereby disrupt normal homeostatic mechanisms that prevent seizures.
Gene_expression (generation) of p25 associated with targeted disruption and convulsion
18) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.87 Pain Relevance 0.10
Since Cdk5 KO mice displayed elevated neuronal excitability and susceptibility to seizures, we examined the levels of p25 in Cdk5 KO mice.
Spec (examined) Gene_expression (levels) of p25 in neuronal associated with targeted disruption, convulsion and neuronal excitability
19) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.24 Pain Relevance 0.27
Chronic loss of Cdk5 is associated with both seizures and reduced levels of p25.
Gene_expression (levels) of p25 associated with convulsion
20) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.31 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox