INT134472

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.25
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Cdk5r1) plasma membrane (Cdk5r1) nucleus (Cdk5r1)
embryo development (Cdk5r1) cell cycle (Cdk5r1) kinase activity (Cdk5r1)
Anatomy Link Frequency
brain 1
Cdk5r1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 24 98.04 Very High Very High Very High
Hippocampus 12 91.16 High High
depression 16 86.40 High High
Neuronal excitability 34 85.12 High High
Peripheral nervous system 1 76.08 Quite High
Inflammation 4 75.84 Quite High
Pain 6 75.00 Quite High
Glutamate receptor 1 58.96 Quite High
Glutamate 1 57.72 Quite High
medulla 4 53.72 Quite High
Disease Link Frequency Relevance Heat
Convulsion 136 99.92 Very High Very High Very High
Cv General 4 Under Development 5 98.04 Very High Very High Very High
Shock 20 97.68 Very High Very High Very High
Sclerosis 4 97.20 Very High Very High Very High
Death 32 95.60 Very High Very High Very High
Status Epilepticus 14 93.24 High High
Targeted Disruption 156 91.96 High High
Apoptosis 4 90.40 High High
Depression 16 86.40 High High
Epilepsy 32 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The monomeric form of Cdk5 is inactive and requires the association of p35 or p39 in order to perform its kinase activity.
p35 Binding (association) of
1) Confidence 0.26 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.40 Pain Relevance 0.18
Generation of p25 was also analyzed following electrical electroconvulsive shock.
p25 Binding (Generation) of associated with shock
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.40 Pain Relevance 0.15
There may be common mechanistic features between loss of Cdk5 and diversion of Cdk5 to form a complex with p25.
p25 Binding (complex) of
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.50 Pain Relevance 0.12
CDK5 activity in the brain is triggered by its binding partners p39 and p35 [12].
p35 Binding (binding) of in brain
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.95 Pain Relevance 0.21

General Comments

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